Autophagy and proteins involved in vesicular trafficking

被引：78

作者：

Amaya, Celina ^{[1
]}

Marcelo Fader, Claudio ^{[1
]}

Isabel Colombo, Maria ^{[1
]}

机构：

[1] Univ Nacl Cuyo, Fac Ciencias Med, Inst Histol & Embriol IHEM CONICET, Lab Biol Celular & Mol, RA-5500 Mendoza, Argentina

来源：

FEBS LETTERS | 2015年 / 589卷 / 22期

关键词：

Autophagy; Rab GTPase; SNAP receptor; Autophagosome biogenesis; Autophagosome-lysosome fusion; SMALL GTPASE; PROMOTES AUTOPHAGY; MEMBRANE-FUSION; MULTIVESICULAR BODIES; NEGATIVE REGULATOR; OXIDATIVE STRESS; PLASMA-MEMBRANE; WIPI PROTEINS; LONGIN DOMAIN; RAB24; GTPASE;

D O I：

10.1016/j.febslet.2015.09.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is an intracellular degradation system that, as a basic mechanism it delivers cytoplasmic components to the lysosomes in order to maintain adequate energy levels and cellular homeostasis. This complex cellular process is activated by low cellular nutrient levels and other stress situations such as low ATP levels, the accumulation of damaged proteins or organelles, or pathogen invasion. Autophagy as a multistep process involves vesicular transport events leading to tethering and fusion of autophagic vesicles with several intracellular compartments. This review summarizes our current understanding of the autophagic pathway with emphasis in the trafficking machinery (i.e. Rabs GTPases and SNAP receptors (SNAREs)) involved in specific steps of the pathway. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3343 / 3353

页数：11

共 138 条

[1] Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion [J].