Synthesis of Benzofuranones via Palladium-Catalyzed Intramolecular Alkoxycarbonylation of Alkenylphenols

被引：16

作者：

Hirschbeck, Vera ^{[1
]}

Fleischer, Ivana ^{[2
]}

机构：

[1] Univ Tubingen, Dept Organ Chem, Auf Morgenstelle 18, D-72076 Tubingen, Germany

[2] Univ Regensburg, Dept Organ Chem, Univ Str 31, D-93053 Regensburg, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 12期

关键词：

carbonylation; CO surrogate; cyclization; lactones; palladium; HIGHLY SELECTIVE FORMATION; CO-SOURCE; ASTERISK-CARBONYLIERUNG; N-FORMYLSACCHARIN; RING LACTONES; ALKENES; METHOXYCARBONYLATION; HYDROESTERIFICATION; DERIVATIVES; ACID;

D O I：

10.1002/chem.201705808

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, a new catalytic system to synthesize benzofuranones is reported. A palladium-catalyzed intramolecular alkoxycarbonylation is employed to generate 3-substituted-benzofuran-2(3H)-ones from alkenylphenols under mild reaction conditions, linked to an ex situ formation of CO from N-formylsaccharin. The carefully chosen catalytic system enables an efficient reaction with a novel functional group tolerance, despite the high polymerization tendency of the starting material.

引用

页码：2854 / 2857

页数：4

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