Discovery of soluble epoxide hydrolase inhibitors from natural products

被引:26
|
作者
Lee, Gwan Ho [1 ]
Oh, Soo Jin [2 ]
Lee, Sang Yoon [1 ]
Lee, Ji-Yoon [1 ]
Ma, Jin Yeul [3 ]
Kim, Young Ho [1 ]
Kim, Sang Kyum [1 ]
机构
[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea
[2] KRIBB, Bioevaluat Ctr, Ochang 363883, Chungbuk, South Korea
[3] Korea Inst Oriental Med, TKM Based Herbal Drug Dev Grp, Taejon 305811, South Korea
关键词
Soluble epoxide hydrolase; Selectivity; Honokiol; beta-Amyrin acetate; PERFORMANCE LIQUID-CHROMATOGRAPHY; EPOXYGENASE-DERIVED EICOSANOIDS; DAMMARANE-TYPE SAPONINS; EPOXYEICOSATRIENOIC ACIDS; ARACHIDONIC-ACID; ACANTHOPANAX-KOREANUM; MAGNOLIA-OFFICINALIS; SCAVENGING CAPACITY; MASS-SPECTROMETRY; STEAMED LEAVES;
D O I
10.1016/j.fct.2013.11.042
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
With the goal of developing soluble epoxide hydrolase (sEH) inhibitors with novel chemical structures, the sEH inhibitory activities of 30 natural compounds were evaluated using both a fluorescent substrate, 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester- 2-oxiraneacetic acid, and a physiological substrate, 14,15-epoxyeicosatrienoic acid. To evaluate the selectivity of sEH inhibition, the inhibition of microsomal epoxide hydrolase (mEH), which plays a critical role in detoxification of toxic epoxides, was determined using human liver microsomes. Honokiol and beta-amyrin acetate, isolated from Magnolia officinalis and Acer mandshuricum, respectively, displayed strong inhibition of sEH activity, with respective IC50 values of 0.57 mu M and 3.4 mu M determined using the fluorescent substrate, and 1.7 mu M and 6.1 mu M determined using 14,15-epoxyeicosatrienoic acid. mEH activity was decreased to 49% or 61% of control activity by 25 mu M honokiol or beta-amyrin acetate, respectively. These results suggest that beta-amyrin acetate and honokiol exhibit sEH inhibitory activity, although their sEH selectivity should be improved. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:225 / 230
页数:6
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