A Fluorescent Probe for Investigating the Activation of Anticancer Platinum(IV) Prodrugs Based on the Cisplatin Scaffold

被引：50

作者：

Montagner, Diego ^{[1
]}

Yap, Siew Qi ^{[1
]}

Ang, Wee Han ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 45期

关键词：

cancer; confocal microscopy; fluorescence; platinum; prodrugs; IN-VITRO CYTOTOXICITY; CARCINOMA CELL-LINES; CANCER-CELLS; TARGETED DELIVERY; LABELED PLATINUM; DRUG-RESISTANCE; COMPLEXES; DESIGN; DIETHYLDITHIOCARBAMATE; SATRAPLATIN;

D O I：

10.1002/anie.201305734

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Watching closely: A fluorescent probe was engineered to detect the clinically relevant platinum drug cisplatin within a complex cellular environment, thus providing a direct means for visualizing its cell entry and the activation of platinum(IV) prodrugs in cancer cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11785 / 11789

页数：5

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