Animal models of axon regeneration after spinal cord injury

被引：45
作者：
Lee, Do-Hun [1 ]
Lee, Jae K. [1 ]
机构：
[1] Univ Miami, Sch Med, Miami Project Cure Paralysis, Dept Neurol Surg, Miami, FL 33136 USA
来源：
NEUROSCIENCE BULLETIN | 2013年 / 29卷 / 04期
关键词：
pyramidotomy; strain differences; contusion; injury models; CORTICOSPINAL TRACT; FUNCTIONAL RECOVERY; CONTUSION INJURY; DEFICIENT MICE; GROWTH; MOUSE; RAT; LESION; PLASTICITY; STRAINS;
D O I：
10.1007/s12264-013-1365-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
With advances in genetic and imaging techniques, investigating axon regeneration after spinal cord injury in vivo is becoming more common in the literature. However, there are many issues to consider when using animal models of axon regeneration, including species, strains and injury models. No single particular model suits all types of experiments and each hypothesis being tested requires careful selection of the appropriate animal model. in this review, we describe several commonly-used animal models of axon regeneration in the spinal cord and discuss their advantages and disadvantages.
引用
收藏
页码：436 / 444
页数：9
相关论文
共 57 条
  • [1] Survival, integration, and axon growth support of glia transplanted into the chronically contused spinal cord
    Barakat, DJ
    Gaglani, SM
    Neravetla, SR
    Sanchez, AR
    Andrade, CM
    Pressman, Y
    Puzis, R
    Garg, MS
    Bunge, MB
    Pearse, DD
    [J]. CELL TRANSPLANTATION, 2005, 14 (04) : 225 - 240
  • [2] Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury
    Bareyre, FM
    Kerschensteiner, M
    Misgeld, T
    Sanes, JR
    [J]. NATURE MEDICINE, 2005, 11 (12) : 1355 - 1360
  • [3] Basso mouse scale for locomotion detects differences in recovery after spinal cord in ury in five common mouse strains
    Basso, DM
    Fisher, LC
    Anderson, AJ
    Jakeman, LB
    McTigue, DM
    Popovich, PG
    [J]. JOURNAL OF NEUROTRAUMA, 2006, 23 (05) : 635 - 659
  • [4] Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: Superiority to camp-mediated effects
    Blesch, Armin
    Lu, Paul
    Tsukada, Shingo
    Alto, Laura Taylor
    Roet, Kasper
    Coppola, Giovanni
    Geschwind, Dan
    Tuszynski, Mark H.
    [J]. EXPERIMENTAL NEUROLOGY, 2012, 235 (01) : 162 - 173
  • [5] CORTICOSPINAL TERMINATIONS IN 2 NEW-WORLD PRIMATES - FURTHER EVIDENCE THAT CORTICOMOTONEURONAL CONNECTIONS PROVIDE PART OF THE NEURAL SUBSTRATE FOR MANUAL DEXTERITY
    BORTOFF, GA
    STRICK, PL
    [J]. JOURNAL OF NEUROSCIENCE, 1993, 13 (12) : 5105 - 5118
  • [6] Ipsilateral, ventral corticospinal tract of the adult rat:: Ultrastructure, myelination and synaptic connections
    Brösamle, C
    Schwab, ME
    [J]. JOURNAL OF NEUROCYTOLOGY, 2000, 29 (07): : 499 - 507
  • [7] Brosamle C, 1997, J COMP NEUROL, V386, P293, DOI 10.1002/(SICI)1096-9861(19970922)386:2<293::AID-CNE9>3.0.CO
  • [8] 2-X
  • [9] Axonal growth therapeutics: regeneration or sprouting or plasticity?
    Cafferty, William B. J.
    Mcgee, Aaron W.
    Strittmatter, Stephen M.
    [J]. TRENDS IN NEUROSCIENCES, 2008, 31 (05) : 215 - 220
  • [10] The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth
    Cafferty, William B. J.
    Strittmatter, Stephen M.
    [J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (47) : 12242 - 12250
123456