Autonomic nerve development contributes to prostate cancer progression

被引:12
作者
Bauman, John [1 ]
McVary, Kevin [1 ]
机构
[1] So Illinois Univ, Sch Med, Div Urol, Springfield, IL 62794 USA
关键词
BLOCKERS; THERAPY;
D O I
10.1038/aja.2013.113
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
In a significant translational study, Magnon et al. investigated the role that the autonomic nervous system plays in the development and spread of prostate cancer in both mice and human models. The study shows different roles for both branches of the autonomic nervous system, with the sympathetic system promoting early stages of tumorigenesis, and the parasympathetic system promoting cancer dissemination. This information could lead to important new foundations for treatment, therapies and management of prostate cancer.
引用
收藏
页码:713 / 714
页数:2
相关论文
共 6 条
[1]   Perineural invasion and Gleason 7-10 tumors predict increased failure in prostate cancer patients with pretreatment PSA<10 ng/ml treated with conformal external beam radiation therapy [J].
Anderson, PR ;
Hanlon, AL ;
Patchefsky, A ;
Al-Saleem, T ;
Hanks, GE .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 41 (05) :1087-1092
[2]   Use of β-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapy [J].
Grytli, Helene Hartvedt ;
Fagerland, Morten Wang ;
Fossa, Sophie D. ;
Tasken, Kristin Austlid ;
Haheim, Lise Lund .
PROSTATE, 2013, 73 (03) :250-260
[3]   Autonomic Nerve Development Contributes to Prostate Cancer Progression [J].
Magnon, Claire ;
Hall, Simon J. ;
Lin, Juan ;
Xue, Xiaonan ;
Gerber, Leah ;
Freedland, Stephen J. ;
Frenette, Paul S. .
SCIENCE, 2013, 341 (6142) :143-+
[4]   GROWTH OF THE RAT PROSTATE-GLAND IS FACILITATED BY THE AUTONOMIC NERVOUS-SYSTEM [J].
MCVARY, KT ;
RAZZAQ, A ;
LEE, C ;
VENEGAS, MF ;
RADEMAKER, A ;
MCKENNA, KE .
BIOLOGY OF REPRODUCTION, 1994, 51 (01) :99-107
[5]   The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by β-blockers [J].
Palm, D ;
Lang, K ;
Niggemann, B ;
Drell, TL ;
Masur, K ;
Zaenker, KS ;
Entschladen, F .
INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (11) :2744-2749
[6]   Cholinergic innervation and muscarinic receptors in the human prostate [J].
Witte, Lambertus P. W. ;
Chapple, Christopher R. ;
de la Rosette, Jean J. M. C. H. ;
Michel, Martin C. .
EUROPEAN UROLOGY, 2008, 54 (02) :326-334