Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria

被引：60
作者：
Yuan, Hushan [1 ]
Cho, Hoonsung [1 ]
Chen, Howard H. [2 ]
Panagia, Marcelo [2 ,3 ]
Sosnovik, David E. [2 ,3 ]
Josephson, Lee [1 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Adv Med Imaging Sci, Charlestown, MA 02129 USA
[2] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 88期
关键词：
MOLECULES; CELLS;
D O I：
10.1039/c3cc45802d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Triphenylphosphonium-fluorochromes (TPP-fluorochromes) are a new class of spectrally variable, mitochondrially targeted probes, with an [F-18] labeling option which, when enabled, allows imaging of a cardiac perfusion deficit using PET/CT.
引用
收藏
页码：10361 / 10363
页数：3
相关论文
共 15 条
  • [1] Fluorescence Tomography of Rapamycin-Induced Autophagy and Cardioprotection In Vivo
    Chen, Howard H.
    Mekkaoui, Choukri
    Cho, Hoonsung
    Ngoy, Soeun
    Marinelli, Brett
    Waterman, Peter
    Nahrendorf, Matthias
    Liao, Ronglih
    Josephson, Lee
    Sosnovik, David E.
    [J]. CIRCULATION-CARDIOVASCULAR IMAGING, 2013, 6 (03) : 441 - +
  • [2] Chen L.B., 1989, Methods Cell Biol, V29, P103
  • [3] PROBING MITOCHONDRIA IN LIVING CELLS WITH RHODAMINE-123
    CHEN, LB
    SUMMERHAYES, IC
    JOHNSON, LV
    WALSH, ML
    BERNAL, SD
    LAMPIDIS, TJ
    [J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1981, 46 : 141 - 155
  • [4] DAVIS S, 1985, J BIOL CHEM, V260, P3844
  • [5] MITOCHONDRIAL-MEMBRANE POTENTIAL ESTIMATED WITH THE CORRECTION OF PROBE BINDING
    DEMURA, M
    KAMO, N
    KOBATAKE, Y
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 894 (03) : 355 - 364
  • [6] HYDROPHOBIC ACRIDINE-DYES FOR FLUORESCENCE STAINING OF MITOCHONDRIA IN LIVING CELLS .2. COMPARISON OF STAINING OF LIVING AND FIXED HELA-CELLS WITH NAO AND DPPAO
    ERBRICH, U
    SEPTINUS, M
    NAUJOK, A
    ZIMMERMANN, HW
    [J]. HISTOCHEMISTRY, 1984, 80 (04) : 385 - 388
  • [7] Autophagy During Cardiac Stress: Joys and Frustrations of Autophagy
    Gottlieb, Roberta A.
    Mentzer, Robert M., Jr.
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2010, 72 : 45 - 59
  • [8] High resolution imaging of live mitochondria
    Jakobs, Stefan
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2006, 1763 (5-6): : 561 - 575
  • [9] The role of coordination chemistry in the development of target-specific radiopharmaceuticals
    Liu, S
    [J]. CHEMICAL SOCIETY REVIEWS, 2004, 33 (07) : 445 - 461
  • [10] Madar I, 2006, J NUCL MED, V47, P1359
12