A new norcembranoid dimer from the Red Sea soft coral Sinularia gardineri

被引：55

作者：

ElSayed, KA ^{[1
]}

Hamann, MT ^{[1
]}

机构：

[1] UNIV MISSISSIPPI,SCH PHARM,DEPT PHARMACOGNOSY,UNIVERSITY,MS 38677

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 07期

关键词：

D O I：

10.1021/np960207z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A study of Sinularia gardineri (Pratt) (Alcyoniidae), collected in the Red Sea, revealed a new heptacyclic norcembranoid dimer singardin (1). The structure of singardin was deduced by spectroscopic analysis. A known sesquiterpene, guaianediol (2), and the known cembranolides (1R,5S,8R, 10S,11R)-11-hydroxy-1-isoprenyl-8-methyl-3,6-dioxo-5,8-epoxycyclotetradec-12-ene 10,12-carbolactone (5-epi-sinuleptolide) and sinuleptolide were also isolated. Compounds 1 and 2 show cytotoxicity to murine leukemia (P-388), human lung carcinoma (A-549), human colon carcinoma (HT-29), and human melanoma cells (MEL-28).

引用

页码：687 / 689

页数：3

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