Impact of portal vein thrombosis on the efficacy of endoscopic variceal band ligation

被引：52

作者：

Dell'Era, Alessandra ^{[1
,2
]}

Iannuzzi, Francesca ^{[1
,2
]}

Fabris, Federica M. ^{[2
]}

Fontana, Paola ^{[1
,2
]}

Reati, Raffaella ^{[1
,2
]}

Grillo, Paolo ^{[4
]}

Aghemo, Alessio ^{[3
]}

de Franchis, Roberto ^{[1
,2
]}

Primignani, Massimo ^{[2
]}

机构：

[1] Univ Milan, Osped Policlin Milano, IRCCS Fdn Ca Granda, Dept Med Sci, Milan, Italy

[2] Osped Policlin Milano, IRCCS Fdn Ca Granda, Gastroenterol Unit 3, Milan, Italy

[3] Osped Policlin Milano, IRCCS Fdn Ca Granda, Gastroenterol Unit 1, Milan, Italy

[4] Osped Policlin Milano, IRCCS Fdn Ca Granda, Epidemiol Unit, Milan, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2014年 / 46卷 / 02期

关键词：

Esophageal varices; Endoscopic band ligation; Portal vein thrombosis; RANDOMIZED CONTROLLED-TRIAL; PRIMARY PROPHYLAXIS; CONSENSUS WORKSHOP; BETA-BLOCKERS; ESOPHAGEAL-VARICES; CIRRHOTIC-PATIENTS; PLUS NADOLOL; PREVENTION; HYPERTENSION; PROPRANOLOL;

D O I：

10.1016/j.dld.2013.08.138

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Influence of portal vein thrombosis on efficacy of endoscopic variceal banding in patients with cirrhosis or extrahepatic portal vein obstruction has never been evaluated. Aim of the study was to assess influence of thrombosis on rate and time to eradication in cirrhosis and extrahepatic portal vein obstruction undergoing banding, compared to cirrhotic patients without thrombosis. Methods: Retrospective analysis of 235 consecutive patients (192 with cirrhosis without thrombosis, 22 cirrhosis and thrombosis and 21 extrahepatic portal vein obstruction) who underwent banding. Banding was performed every 2-3 weeks until eradication; endoscopic follow-up was performed at 1, 3, 6 months, then annually. Results: Eradication was achieved in 233 patients. Median time to eradication in cirrhotic patients with portal vein thrombosis vs. cirrhotic patients without thrombosis was 50.9 days (12-440) vs. 43.4 days (13-489.4); log-rank: 0.04; patients with extrahepatic portal vein obstruction vs. cirrhotic patients without thrombosis 63.9 days (31-321.6) vs. 43.4 days (13.0-489.4); log-rank: 0.008. Thrombosis was shown to be the only risk factor for longer time to eradication. Conclusions: Portal vein thrombosis per se appears to be the cause of a longer time to achieve eradication of varices but, once eradication is achieved, it does not influence their recurrence. (C) 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：152 / 156

页数：5

共 29 条

[1]

Cheng CC, 1998, GASTROENTEROLOGY, V114, pA1224

[2] Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators [J].