Mouse models of prostate cancer

被引：48

作者：

Sharma, P ^{[1
]}

Schreiber-Agus, N ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA

来源：

ONCOGENE | 1999年 / 18卷 / 38期

关键词：

mouse model; prostate cancer; transgenic;

D O I：

10.1038/sj.onc.1203037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pathogenetic basis of prostate cancer remains highly elusive; its clarification could be facilitated greatly by laboratory and clinical models of the disease. Although the genetically manipulated mouse has been invaluable for the modeling of other human cancer types, it has fared less well with respect to prostate cancer. Nevertheless, several highly valuable transgenic models exist and are highlighted in this review. Emerging reagents and strategies may allow us to use the mouse more effectively to define the molecular, cellular and physiological events that lead to prostate cancer initiation and progression.

引用

页码：5349 / 5355

页数：7

共 83 条

[1]

[Anonymous], GENETIC BASIS HUMAN

[2]

BARRIOS R, 1996, TRANSGENICS, V2, P23

[3]

BARRIOS R, 1994, TRANSGENICS, V1, P411

[4] Roles for Nkx3.1 in prostate development and cancer [J].

Bhatia-Gaur, R ;

Donjacour, AA ;

Sciavolino, PJ ;

Kim, M ;

Desai, N ;

Young, P ;

Norton, CR ;

Gridley, T ;

Cardiff, RD ;

Cunha, GR ;

Abate-Shen, C ;

Shen, MM .

GENES & DEVELOPMENT, 1999, 13 (08) :966-977

[5]

Brothman AR, 1999, PROSTATE, V38, P303

[6]

Buttyan R, 1997, PROSTATE, V33, P164, DOI 10.1002/(SICI)1097-0045(19971101)33:3<164::AID-PROS3>3.0.CO

[7]

2-J

[8]

CARTER BS, 1990, CANCER RES, V50, P6830

[9] THE MOUSE MAMMARY-TUMOR VIRUS LONG TERMINAL REPEAT DIRECTS EXPRESSION IN EPITHELIAL AND LYMPHOID-CELLS OF DIFFERENT TISSUES IN TRANSGENIC MICE [J].

CHOI, YW ;

HENRARD, D ;

LEE, IC ;

ROSS, SR .

JOURNAL OF VIROLOGY, 1987, 61 (10) :3013-3019

[10] A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans [J].

Cleutjens, KBJM ;

vanderKorput, HAGM ;

EhrenvanEekelen, CC ;

Sikes, RA ;

Fasciana, C ;

Chung, LW ;

Trapman, J .

MOLECULAR ENDOCRINOLOGY, 1997, 11 (09) :1256-1265

← 1 2 3 4 5 6 7 8 9 →