Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide

被引：16

作者：

Dai, Yan ^{[1
,2
]}

Chen, Shao-Ru ^{[1
,2
]}

Chai, Ling ^{[3
,4
]}

Zhao, Jing ^{[1
,2
]}

Wang, Yitao ^{[1
,2
]}

Wang, Ying ^{[1
,2
]}

机构：

[1] Univ Macau, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa, Macao, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, Ave Univ, Taipa, Macao, Peoples R China

[3] Guangxi Inst Tradit Med & Pharmaceut Sci, Nanning 530022, Peoples R China

[4] Guangxi Key Lab Tradit Chinese Med Qual Stand, Nanning 530022, Peoples R China

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2019年 / 59卷

关键词：

Andrographis paniculata; andrographolide; mechanisms of action; structure-activity-relationship; RHEUMATOID-ARTHRITIS; OXIDATIVE STRESS; DOWN-REGULATION; NITRIC-OXIDE; EXTRACT; CELLS; DERIVATIVES; CANCER; EXPRESSION; APOPTOSIS;

D O I：

10.1080/10408398.2018.1501657

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Andrographis paniculata (A. paniculata) is a medicinal plant traditionally used as anti-inflammation and anti-bacteria herb. Andrographolide, the major active component of A. paniculata, exhibits diverse pharmacological activities, including anti-inflammation, anti-cancer, anti-obesity, anti-diabetes, and other activities. In this article, we comprehensively review the therapeutic potential of A. paniculata and andrographolide focusing on the mechanisms of action and clinical application. We systemically discuss the structure-activity relationship of andrographolide and derivatives. Despite the various pharmacological activities and formula of A. paniculata and andrographolide, we propose further development of more structural derivatives of andrographolide with reduced toxicity and increased therapeutic efficacy is still needed for the clinical application of this ancient mighty herb and its major component.

引用

页码：S17 / S29

页数：13

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