Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors

被引：17
|
作者：
Nomelini, Rosekeila Simoes [1 ,2 ]
de Abreu Ribeiro, Livia Carolina [3 ]
Tavares-Murta, Beatriz Martins [3 ]
Adad, Sheila Jorge [4 ]
Candido Murta, Eddie Fernando [1 ]
机构：
[1] Univ Fed Triangulo Mineiro, Res Inst Oncol IPON, Discipline Gynecol & Obstet, BR-38025440 Uberaba, MG, Brazil
[2] Univ Fed Triangulo Mineiro, Discipline Human Anat, BR-38025440 Uberaba, MG, Brazil
[3] Univ Fed Triangulo Mineiro, Discipline Pharmacol, BR-38015050 Uberaba, MG, Brazil
[4] Univ Fed Triangulo Mineiro, Discipline Special Pathol, BR-38025440 Uberaba, MG, Brazil
来源：
MEDIATORS OF INFLAMMATION | 2008年 / 2008卷
关键词：
D O I：
10.1155/2008/186584
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tumor sections from nonneoplastic (n = 15), benign (n = 28), and malignant ovarian tumors (n = 20) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic or benign tumor samples. Using the Griess method, nitric oxide (NO) metabolite levels were also found to be elevated in malignant tumor samples compared to benign tumor samples (P < .05). For stage I ovarian cancer, intracystic NO levels >80 mu M were more frequent than NO levels < 80 mu M, and iNOS expression in well-differentiated carcinomas was greater than in moderately/poorly differentiated carcinomas (P < .05). These data suggest an important role for NO in ovarian carcinogenesis. Copyright (C) 2008 Rosekeila Simoes Nomelini et al.
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页数：7
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