Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices

被引：37

作者：

Battista, Natalia ^{[1
,2
]}

Sergi, Manuel ^{[1
]}

Montesano, Camilla ^{[3
]}

Napoletano, Sabino ^{[3
,4
]}

Compagnone, Dario ^{[1
]}

Maccarrone, Mauro ^{[2
,5
]}

机构：

[1] Univ Teramo, Fac Biosci & Technol Food Agr & Environm, I-64100 Teramo, Italy

[2] Santa Lucia Fdn, European Ctr Brain Res, Rome, Italy

[3] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

[4] Minist Interior, Dept Publ Safety, Forens Serv, GIPS, Ancona, Italy

[5] Univ Rome, Ctr Integrated Res, Rome, Italy

来源：

DRUG TESTING AND ANALYSIS | 2014年 / 6卷 / 1-2期

关键词：

(9)-tetrahydrocannabinol; anandamide; liquid chromatography; mass spectrometry; PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; SOLID-PHASE MICROEXTRACTION; 2-DIMENSIONAL GAS-CHROMATOGRAPHY; 11-NOR-9-CARBOXY-DELTA(9)-TETRAHYDROCANNABINOL THC-COOH; DELTA-9-TETRAHYDROCANNABINOLIC ACID-A; ORAL FLUID SAMPLES; LC-MS/MS METHOD; 11-NOR-DELTA(9)-TETRAHYDROCANNABINOL-9-CARBOXYLIC ACID; WHOLE-BLOOD;

D O I：

10.1002/dta.1574

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the last two decades, the role played by phytocannabinoids and endocannabinoids in medicine has gained increasing interest in the scientific community. Upon identification of the plant compound (9)-tetrahydrocannabinol (THC) and of the endogenous substance anandamide (AEA), different methodological approaches and innovative techniques have been developed, in order to evaluate the content of these molecules in various human matrices. In this review, we discuss the analytical methods that are currently used for the identification of phytocannabinoids and endocannabinoids, and we summarize the benefits and limitations of these procedures. Moreover, we provide an overview of the main biological matrices that have been analyzed to date for qualitative detection and quantitative determination of these compounds. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：7 / 16

页数：10

共 165 条

[31] Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat [J].