Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices

被引：37
作者：
Battista, Natalia [1 ,2 ]
Sergi, Manuel [1 ]
Montesano, Camilla [3 ]
Napoletano, Sabino [3 ,4 ]
Compagnone, Dario [1 ]
Maccarrone, Mauro [2 ,5 ]
机构：
[1] Univ Teramo, Fac Biosci & Technol Food Agr & Environm, I-64100 Teramo, Italy
[2] Santa Lucia Fdn, European Ctr Brain Res, Rome, Italy
[3] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy
[4] Minist Interior, Dept Publ Safety, Forens Serv, GIPS, Ancona, Italy
[5] Univ Rome, Ctr Integrated Res, Rome, Italy
来源：
DRUG TESTING AND ANALYSIS | 2014年 / 6卷 / 1-2期
关键词：
(9)-tetrahydrocannabinol; anandamide; liquid chromatography; mass spectrometry; PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; SOLID-PHASE MICROEXTRACTION; 2-DIMENSIONAL GAS-CHROMATOGRAPHY; 11-NOR-9-CARBOXY-DELTA(9)-TETRAHYDROCANNABINOL THC-COOH; DELTA-9-TETRAHYDROCANNABINOLIC ACID-A; ORAL FLUID SAMPLES; LC-MS/MS METHOD; 11-NOR-DELTA(9)-TETRAHYDROCANNABINOL-9-CARBOXYLIC ACID; WHOLE-BLOOD;
D O I：
10.1002/dta.1574
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the last two decades, the role played by phytocannabinoids and endocannabinoids in medicine has gained increasing interest in the scientific community. Upon identification of the plant compound (9)-tetrahydrocannabinol (THC) and of the endogenous substance anandamide (AEA), different methodological approaches and innovative techniques have been developed, in order to evaluate the content of these molecules in various human matrices. In this review, we discuss the analytical methods that are currently used for the identification of phytocannabinoids and endocannabinoids, and we summarize the benefits and limitations of these procedures. Moreover, we provide an overview of the main biological matrices that have been analyzed to date for qualitative detection and quantitative determination of these compounds. Copyright (c) 2013 John Wiley & Sons, Ltd.
引用
收藏
页码：7 / 16
页数：10
相关论文
共 165 条
  • [1] Development and validation of a method for the quantitation of Δ9 tetrahydrocannabinol in human plasma by high performance liquid chromatography after solid-phase extraction
    Abbara, Chadi
    Galy, Romain
    Benyamina, Amine
    Reynaud, Michel
    Bonhomme-Faivre, Laurence
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 41 (03) : 1011 - 1016
  • [2] Simultaneous GC-El-MS determination of Δ9-tetrahydrocannabinol, 11-hydroxy-Δ9-tetrahydrocannabinol, and 11-nor-9-carboxy, Δ9-tetrahydrocannabinol in human urine following tandem enzyme-alkaline hydrolysis
    Abraham, Tsadik T.
    Lowe, Ross H.
    Pirnay, Stephane O.
    Darwin, William D.
    Huestis, Marilyn A.
    [J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 2007, 31 (08) : 477 - 485
  • [3] Quantitative analysis of anandamide and related acylethanolamides in human seminal plasma by ultra performance liquid chromatography tandem mass spectrometry
    Amoako, Akwasi A.
    Marczylo, Timothy H.
    Lam, Patricia M. W.
    Willets, Jonathon M.
    Derry, Amanda
    Elson, Janine
    Konje, Justin C.
    [J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2010, 878 (31): : 3231 - 3237
  • [4] A validated method for the analysis of cannabinoids in post-mortem blood using liquid-liquid extraction and two-dimensional gas chromatography-mass spectrometry
    Andrews, Rebecca
    Paterson, Sue
    [J]. FORENSIC SCIENCE INTERNATIONAL, 2012, 222 (1-3) : 111 - 117
  • [5] Hair analysis for Δ9-tetrahydrocannabinolic acid A-New insights into the mechanism of drug incorporation of cannabinoids into hair
    Auwaerter, Volker
    Wohlfarth, Ariane
    Traber, Jessica
    Thieme, Detlef
    Weinmann, Wolfgang
    [J]. FORENSIC SCIENCE INTERNATIONAL, 2010, 196 (1-3) : 10 - 13
  • [6] Determination of cannabinoids in hair using high-pH* non-aqueous electrolytes and electrochemical detection - Some aspects of sensitivity and selectivity
    Backofen, U
    Matysik, FM
    Lunte, CE
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2002, 942 (1-2) : 259 - 269
  • [7] Hair analysis for Δ9-THC, Δ9-THC-COOH, CBN and CBD, by GC/MS-EI.: Comparison with GC/MS-NCI for Δ9-THC-COOH
    Baptista, MJ
    Monsanto, PV
    Marques, EGP
    Bermejo, A
    Avila, S
    Castanheira, AM
    Margalho, C
    Barroso, M
    Vieira, DN
    [J]. FORENSIC SCIENCE INTERNATIONAL, 2002, 128 (1-2) : 66 - 78
  • [8] Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes
    Battista, Natalia
    Bari, Monica
    Tarditi, Alessia
    Mariotti, Caterina
    Bachoud-Levi, Anne-Catherine
    Zuccato, Chiara
    Finazzi-Agro, Alessandro
    Genitrini, Silvia
    Peschanski, Marc
    Di Donato, Stefano
    Cattaneo, Elena
    Maccarrone, Mauro
    [J]. NEUROBIOLOGY OF DISEASE, 2007, 27 (01) : 108 - 116
  • [9] The role of endocannabinoids in gonadal function and fertility along the evolutionary axis
    Battista, Natalia
    Meccariello, Rosaria
    Cobellis, Gilda
    Fasano, Silvia
    Di Tommaso, Monia
    Pirazzi, Valentina
    Konje, Justin C.
    Pierantoni, Riccardo
    Maccarrone, Mauro
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 355 (01) : 1 - 14
  • [10] Oral Fluid Testing for Drugs of Abuse
    Bosker, Wendy M.
    Huestis, Marilyn A.
    [J]. CLINICAL CHEMISTRY, 2009, 55 (11) : 1910 - 1931
12345678910