Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism

被引：53

作者：

Andrade, Jacqueline C. ^{[1
]}

Morais Braga, Maria Flaviana B. ^{[1
]}

Guedes, Glaucia Morgana M. ^{[1
]}

Tintino, Saulo R. ^{[1
]}

Freitas, Maria A. ^{[1
]}

Quintans, Lucindo J., Jr. ^{[2
]}

Menezes, Irwin R. A. ^{[1
]}

Coutinho, Henrique D. M. ^{[1
]}

机构：

[1] Univ Reg Cariri, Crato, CE, Brazil

[2] Univ Fed Sergipe, Aracaju, SE, Brazil

来源：

SAUDI JOURNAL OF BIOLOGICAL SCIENCES | 2017年 / 24卷 / 01期

关键词：

Menadione; Lipid solubility; Microdilution; Antibiotic-modifying; Permeabilization;

D O I：

10.1016/j.sjbs.2015.09.004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Menadione, vitamin K3, belongs to the class of lipid-soluble vitamins and lipophilic substances as menadione cause disturbances in the bacterial membrane, resulting in damage to the fundamental elements for the integrity of the membrane, thus allowing increased permeability. Accordingly, the aim of this study was to evaluate in vitro the antibiotic-modifying activity of menadione in multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, with a gradual increase in its subinhibitory concentration. In addition, menadione was compared with cholesterol and ergosterol for similarity in mechanism of drug modulatory action. Antibiotic-modifying activity and antibacterial effect were determined by the broth microdilution assay. Menadione, cholesterol and ergosterol showed modulatory activity at clinically relevant concentrations, characterizing them as modifiers of bacterial drug resistance, since they lowered the MIC of the antibiotics tested. This is the first report of the antibacterial activity of menadione and its potentiation of aminoglycosides against multiresistant bacteria. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：59 / 64

页数：6

共 27 条

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