Fatal self administration of tramadol and propofol: A case report

被引：22

作者：

Mannocchi, Giulio ^{[1
]}

Napoleoni, Francesca ^{[1
]}

Napoletano, Simona ^{[1
]}

Pantano, Flaminia ^{[1
]}

Santoni, Mariangela ^{[1
]}

Tittarelli, Roberta ^{[1
]}

Arbarello, Paolo ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Anat Histol Forens Med & Orthoped Sci, I-00161 Rome, Italy

来源：

JOURNAL OF FORENSIC AND LEGAL MEDICINE | 2013年 / 20卷 / 06期

关键词：

Propofol; Tramadol; Toxicological; Cardiac arrest; GC-MS; OVERDOSE;

D O I：

10.1016/j.jflm.2013.04.003

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

We describe a case of unintentional intoxication due to tramadol and propofol self administration, occurred in a middle aged man, healthcare provider, deceased despite advanced medical assistance an hour later the onset of severe and increasing dyspnea. Toxicological analysis performed with gas chromatography-mass spectrometry in blood sample, evidenced a lethal tramadol concentration and therapeutic level of Propofol. Quantitative determination was also performed in other specimens such as bile, tissues (liver, spleen, kidney) and pubic hair, to assess chronic exposure. Toxicological results and autopsy findings, supported by clinical and hematochemical data, suggested a myocardial damage, associated with respiratory failure. (c) 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

引用

页码：715 / 719

页数：5

共 18 条

[1]

Baselt RC., 2008, Disposition of Toxic Drugs and Chemicals in Man, V8

[2]

Bell D M, 1999, AANA J, V67, P133

[3] Fatal overdoses of trarnadol:: is benzodiazepine a risk factor of lethality? [J].

Clarot, F ;

Goullé, JP ;

Vaz, E ;

Proust, B .

FORENSIC SCIENCE INTERNATIONAL, 2003, 134 (01) :57-61

[4]

Cole JB, 2012, PACING CLIN ELECTROP, V35, P219

[5] Refractory shock and asystole related to tramadol overdose [J].

Daubin, Cedric ;

Quentin, Charlotte ;

Goulle, Jean-Pierre ;

Guillotin, Damien ;

Lehoux, Philippe ;

Lepage, Olivier ;

Charbonneau, Pierre .

CLINICAL TOXICOLOGY, 2007, 45 (08) :961-964

[6] Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer [J].

Elkalioubie, Ahmed ;

Allorge, Delphine ;

Robriquet, Laurent ;

Wiart, Jean-Francois ;

Garat, Anne ;

Broly, Franck ;

Fourrier, Francois .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 67 (08) :855-858

[7] Electrocardiographic manifestations of tramadol toxicity with special reference to their ability for prediction of seizures [J].

Emamhadi, Mohammadali ;

Sanaei-Zadeh, Hossein ;

Nikniya, Masoumeh ;

Zamani, Nasim ;

Dart, Richard C. .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2012, 30 (08) :1481-1485

[8] Tramadol overdose and serotonin syndrome manifesting as acute right heart dysfunction [J].

Garrett, PM .

ANAESTHESIA AND INTENSIVE CARE, 2004, 32 (04) :575-577

[9] Evidence of addiction by anesthesiologists as documented by hair analysis [J].

Kintz, P ;

Villain, M ;

Dumestre, V ;

Cirimele, V .

FORENSIC SCIENCE INTERNATIONAL, 2005, 153 (01) :81-84

[10] Evaluation of a fatal propofol intoxication due to self administration [J].

Klausz, Gabriella ;

Rona, Kalman ;

Kristof, Istvan ;

Toero, Klara .

JOURNAL OF FORENSIC AND LEGAL MEDICINE, 2009, 16 (05) :287-289

← 1 2 →