Pharmacology of Iron Transport

被引：25
作者：
Byrne, Shaina L. [1 ]
Krishnamurthy, Divya [1 ]
Wessling-Resnick, Marianne [1 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
来源：
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 | 2013年 / 53卷
关键词：
hepcidin; hemochromatosis; transferrin; DMT1; NTBI; CELL LUNG-CANCER; PYRIDOXAL ISONICOTINOYL HYDRAZONE; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE 3-AP; AMYLOID PRECURSOR PROTEIN; TRANSFERRIN-BOUND IRON; RIBONUCLEOTIDE REDUCTASE INHIBITOR; RECEPTOR-MEDIATED ENDOCYTOSIS; DIVALENT METAL TRANSPORTER-1; SMALL-MOLECULE INHIBITORS; FREE-RADICAL REACTIONS;
D O I：
10.1146/annurev-pharmtox-010611-134648
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Elucidating the molecular basis for the regulation of iron uptake, storage, and distribution is necessary to understand iron homeostasis. Pharmacological tools are emerging to identify and distinguish among different iron transport pathways. Stimulatory or inhibitory small molecules with effects on iron uptake can help characterize the mechanistic elements of iron transport and the roles of the transporters involved in these processes. In particular, iron chelators can serve as potential pharmacological tools to alleviate diseases of iron overload. This review focuses on the pharmacology of iron transport, introducing iron transport membrane proteins and known inhibitors.
引用
收藏
页码：17 / 36
页数：20
相关论文
共 173 条
  • [41] Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
    Duce, James A.
    Tsatsanis, Andrew
    Cater, Michael A.
    James, Simon A.
    Robb, Elysia
    Wikhe, Krutika
    Leong, Su Ling
    Perez, Keyla
    Johanssen, Timothy
    Greenough, Mark A.
    Cho, Hyun-Hee
    Galatis, Denise
    Moir, Robert D.
    Masters, Colin L.
    McLean, Catriona
    Tanzi, Rudolph E.
    Cappai, Roberto
    Barnham, Kevin J.
    Ciccotosto, Giuseppe D.
    Rogers, Jack T.
    Bush, Ashley I.
    [J]. CELL, 2010, 142 (06) : 857 - 867
  • [42] DUMONT E, 1995, METHOD FIND EXP CLIN, V17, P83
  • [43] A novel iron-regulated metal transporter from plants identified by functional expression in yeast
    Eide, D
    Broderius, M
    Fett, J
    Guerinot, ML
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) : 5624 - 5628
  • [44] METAL-IONS CATALYTIC FOR FREE-RADICAL REACTIONS IN THE PLASMA OF PATIENTS WITH FULMINANT HEPATIC-FAILURE
    EVANS, PJ
    EVANS, RW
    BOMFORD, A
    WILLIAMS, R
    HALLIWELL, B
    [J]. FREE RADICAL RESEARCH, 1994, 20 (03) : 139 - 144
  • [45] DIMINISHED IRON ACQUISITION BY CELLS AND TISSUES OF BELGRADE LABORATORY RATS
    FARCICH, EA
    MORGAN, EH
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (02): : R220 - R224
  • [46] UPTAKE OF TRANSFERRIN-BOUND AND NONTRANSFERRIN-BOUND IRON BY RETICULOCYTES FROM THE BELGRADE LABORATORY RAT - COMPARISON WITH WISTAR RAT TRANSFERRIN AND RETICULOCYTES
    FARCICH, EA
    MORGAN, EH
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 1992, 39 (01) : 9 - 14
  • [47] The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
    Feder, JN
    Penny, DM
    Irrinki, A
    Lee, VK
    Lebrón, JA
    Watson, N
    Tsuchihashi, Z
    Sigal, E
    Bjorkman, PJ
    Schatzman, RC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) : 1472 - 1477
  • [48] A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    Feder, JN
    Gnirke, A
    Thomas, W
    Tsuchihashi, Z
    Ruddy, DA
    Basava, A
    Dormishian, F
    Domingo, R
    Ellis, MC
    Fullan, A
    Hinton, LM
    Jones, NL
    Kimmel, BE
    Kronmal, GS
    Lauer, P
    Lee, VK
    Loeb, DB
    Mapa, FA
    McClelland, E
    Meyer, NC
    Mintier, GA
    Moeller, N
    Moore, T
    Morikang, E
    Prass, CE
    Quintana, L
    Starnes, SM
    Schatzman, RC
    Brunke, KJ
    Drayna, DT
    Risch, NJ
    Bacon, BR
    Wolff, RK
    [J]. NATURE GENETICS, 1996, 13 (04) : 399 - 408
  • [49] Fleming MD, 1997, NAT GENET, V16, P383, DOI 10.1038/ng0897-383
  • [50] Nramp2 is mutated in the anemic Belgrade (b) rat:: Evidence of a role for Nramp2 in endosomal iron transport
    Fleming, MD
    Romano, MA
    Su, MA
    Garrick, LM
    Garrick, MD
    Andrews, NC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (03) : 1148 - 1153
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