Pharmacology of Iron Transport

被引：25
作者：
Byrne, Shaina L. [1 ]
Krishnamurthy, Divya [1 ]
Wessling-Resnick, Marianne [1 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
来源：
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 | 2013年 / 53卷
关键词：
hepcidin; hemochromatosis; transferrin; DMT1; NTBI; CELL LUNG-CANCER; PYRIDOXAL ISONICOTINOYL HYDRAZONE; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE 3-AP; AMYLOID PRECURSOR PROTEIN; TRANSFERRIN-BOUND IRON; RIBONUCLEOTIDE REDUCTASE INHIBITOR; RECEPTOR-MEDIATED ENDOCYTOSIS; DIVALENT METAL TRANSPORTER-1; SMALL-MOLECULE INHIBITORS; FREE-RADICAL REACTIONS;
D O I：
10.1146/annurev-pharmtox-010611-134648
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Elucidating the molecular basis for the regulation of iron uptake, storage, and distribution is necessary to understand iron homeostasis. Pharmacological tools are emerging to identify and distinguish among different iron transport pathways. Stimulatory or inhibitory small molecules with effects on iron uptake can help characterize the mechanistic elements of iron transport and the roles of the transporters involved in these processes. In particular, iron chelators can serve as potential pharmacological tools to alleviate diseases of iron overload. This review focuses on the pharmacology of iron transport, introducing iron transport membrane proteins and known inhibitors.
引用
收藏
页码：17 / 36
页数：20
相关论文
共 173 条
  • [161] Editorial
    Xiao, Shu Dong
    [J]. JOURNAL OF DIGESTIVE DISEASES, 2010, 11 (01) : 1 - 1
  • [162] A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway
    Xu, HX
    Jin, J
    DeFelice, LJ
    Andrews, NC
    Clapham, DE
    [J]. PLOS BIOLOGY, 2004, 2 (03) : 378 - 386
  • [163] Ebselen in acute ischemic stroke - A placebo-controlled, double-blind clinical trial
    Yamaguchi, T
    Sano, K
    Takakura, K
    Saito, I
    Shinohara, Y
    Asano, T
    Yasuhara, H
    [J]. STROKE, 1998, 29 (01) : 12 - 17
  • [164] Inhibition of iron transport across human intestinal epithelial cells by hepcidin
    Yamaji, S
    Sharp, P
    Ramesh, B
    Srai, SK
    [J]. BLOOD, 2004, 104 (07) : 2178 - 2180
  • [165] Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators - A lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28
    Youdim, MBH
    Stephenson, G
    Ben Shachar, D
    [J]. REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS, 2004, 1012 : 306 - 325
  • [166] Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors
    Yu, Yu
    Kalinowski, Danuta S.
    Kovacevic, Zaklina
    Siafakas, Aritee R.
    Jansson, Patric J.
    Stefani, Christian
    Lovejoy, David B.
    Sharpe, Philip C.
    Bernhardt, Paul V.
    Richardson, Des R.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (17) : 5271 - 5294
  • [167] Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria
    Zhang, AS
    Sheftel, AD
    Ponka, P
    [J]. BLOOD, 2005, 105 (01) : 368 - 375
  • [168] The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae
    Zhao, H
    Eide, D
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (38) : 23203 - 23210
  • [169] The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation
    Zhao, H
    Eide, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) : 2454 - 2458
  • [170] ZRT/IRT-like Protein 14 (ZIP14) Promotes the Cellular Assimilation of Iron from Transferrin
    Zhao, Ningning
    Gao, Junwei
    Enns, Caroline A.
    Knutson, Mitchell D.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (42) : 32141 - 32150
9101112131415161718