Pharmacology of Iron Transport

被引：25
作者：
Byrne, Shaina L. [1 ]
Krishnamurthy, Divya [1 ]
Wessling-Resnick, Marianne [1 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
来源：
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 | 2013年 / 53卷
关键词：
hepcidin; hemochromatosis; transferrin; DMT1; NTBI; CELL LUNG-CANCER; PYRIDOXAL ISONICOTINOYL HYDRAZONE; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE 3-AP; AMYLOID PRECURSOR PROTEIN; TRANSFERRIN-BOUND IRON; RIBONUCLEOTIDE REDUCTASE INHIBITOR; RECEPTOR-MEDIATED ENDOCYTOSIS; DIVALENT METAL TRANSPORTER-1; SMALL-MOLECULE INHIBITORS; FREE-RADICAL REACTIONS;
D O I：
10.1146/annurev-pharmtox-010611-134648
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Elucidating the molecular basis for the regulation of iron uptake, storage, and distribution is necessary to understand iron homeostasis. Pharmacological tools are emerging to identify and distinguish among different iron transport pathways. Stimulatory or inhibitory small molecules with effects on iron uptake can help characterize the mechanistic elements of iron transport and the roles of the transporters involved in these processes. In particular, iron chelators can serve as potential pharmacological tools to alleviate diseases of iron overload. This review focuses on the pharmacology of iron transport, introducing iron transport membrane proteins and known inhibitors.
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收藏
页码：17 / 36
页数：20
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