Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure

被引：68
作者：
Pawlak, D
Tankiewicz, A
Mysliwiec, P
Buczko, W
机构：
[1] Med Acad Bialystok, Dept Pharmacodynam, PL-15230 Bialystok, Poland
[2] Med Acad Bialystok, Dept Gen Surg 2, PL-15230 Bialystok, Poland
来源：
NEPHRON | 2002年 / 90卷 / 03期
关键词：
tryptophan; kynurenine; 3-hydroxykynurenine; kynurenic acid; xathurenic acid; anthranilic acid; quinolinic acid; renal failure;
D O I：
10.1159/000049069
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Background. Kidneys are involved in tryptophan (TRP) metabolism in two ways. They eliminate TRP derivatives on the one hand, and they produce several enzymes taking part in TRP metabolism mainly via the kynurenine pathway on the other. The aim of the present study was to examine the time-course of changes in the peripheral kynurenine products degradation during experimental chronic renal failure in rats. Methods: Tryptophan, kynurenine, 3-hydroxykynurenine, kynurenic acid, xanthurenic acid, anthranilic acid and quinolinic acid were determined in plasma using high-performance liquid chromatography technique with UV, fluorescence and electrochemical detection. Results: A decreased TRP level and significant increase in kynurenine pathway metabolite concentrations in plasma of uremic rats were found. Conclusions: Substantial disturbances in the peripheral kynurenic pathway were observed in experimental chronic renal failure. They may contribute to several symptoms of uremia. Copyright (C) 2002 S. Karger AG, Basel.
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页码：328 / 335
页数：8
相关论文
共 33 条
[1]  
Bertazzo A, 1999, ADV EXP MED BIOL, V467, P565
[2]   QUINOLINIC ACID ACCUMULATION AND FUNCTIONAL DEFICITS FOLLOWING EXPERIMENTAL SPINAL-CORD INJURY [J].
BLIGHT, AR ;
COHEN, TI ;
SAITO, K ;
HEYES, MP .
BRAIN, 1995, 118 :735-752
[3]   CLONING AND FUNCTIONAL EXPRESSION OF A SOLUBLE FORM OF KYNURENINE ALPHA-AMINOADIPATE AMINOTRANSFERASE FROM RAT-KIDNEY [J].
BUCHLI, R ;
ALBERATIGIANI, D ;
MALHERBE, P ;
KOHLER, C ;
BROGER, C ;
CESURA, AM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (49) :29330-29335
[4]   Effect of cytokines on growth of Toxoplasma gondii in murine astrocytes [J].
Halonen, SK ;
Chiu, FC ;
Weiss, LM .
INFECTION AND IMMUNITY, 1998, 66 (10) :4989-4993
[5]   Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection [J].
Herve, C ;
Beyne, P ;
Jamault, H ;
Delacoux, E .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1996, 675 (01) :157-161
[6]   Human microglia convert L-tryptophan into the neurotoxin quinolinic acid [J].
Heyes, MP ;
Achim, CL ;
Wiley, CA ;
Major, EO ;
Saito, K ;
Markey, SP .
BIOCHEMICAL JOURNAL, 1996, 320 :595-597
[7]   QUANTIFICATION OF 3-HYDROXYKYNURENINE IN BRAIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND ELECTROCHEMICAL DETECTION [J].
HEYES, MP ;
QUEARRY, BJ .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 428 (02) :340-344
[8]   Potentiation of interferon-induced indoleamine 2,3-dioxygenase mRNA in human mononuclear phagocytes by lipopolysaccharide and interleukin-1 [J].
Hissong, BD ;
Carlin, JM .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1997, 17 (07) :387-393
[9]   2-Oxoacids regulate kynurenic acid production in the rat brain: Studies in vitro and in vivo [J].
Hodgkins, PS ;
Wu, HQ ;
Zielke, HR ;
Schwarcz, R .
JOURNAL OF NEUROCHEMISTRY, 1999, 72 (02) :643-651
[10]   TRYPTOPHAN DISTRIBUTION AND METABOLISM IN EXPERIMENTAL CHRONIC RENAL-INSUFFICIENCY [J].
HOLMES, EW ;
KAHN, SE .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1987, 46 (01) :89-101
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