Macrophage Function and Polarization in Cardiovascular Disease A Role of Estrogen Signaling?

被引：74

作者：

Bolego, Chiara ^{[1
]}

Cignarella, Andrea ^{[1
]}

Staels, Bart ^{[2
,3
,4
,5
,6
]}

Chinetti-Gbaguidi, Giulia ^{[2
,3
,4
,5
,6
]}

机构：

[1] Univ Padua, Dept Pharmaceut & Pharmacol Sci, I-35131 Padua, Italy

[2] Univ Lille Nord France, Lille, France

[3] INSERM, U1011, F-59045 Lille, France

[4] UDSL, Lille, France

[5] Inst Pasteur, F-59019 Lille, France

[6] European Genom Inst Diabet, Lille, France

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2013年 / 33卷 / 06期

关键词：

adipose tissue; cardiovascular disease; estrogen; macrophages; nuclear receptors; MONOCYTE-DERIVED MACROPHAGES; IMPROVES INSULIN-RESISTANCE; HIGH-FAT DIET; RECEPTOR-ALPHA; PPAR-GAMMA; TRANSCRIPTION FACTOR; DENDRITIC CELLS; ADIPOSE-TISSUE; IN-VIVO; ALTERNATIVE ACTIVATION;

D O I：

10.1161/ATVBAHA.113.301328

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Macrophages are plastic and versatile cells adapting their function/phenotype to the microenvironment. Distinct macrophage subpopulations with different functions, including classically (M1) and (M2) activated macrophages, have been described. Reciprocal skewing of macrophage polarization between the M1 and M2 state is a process modulated by transcription factors, such as the nuclear peroxisome proliferator-activated receptors. However, whether the estrogen/estrogen receptor pathways control the balance between M1/M2 macrophages is only partially understood. Estrogen-dependent effects on the macrophage system may be regarded as potential targets of pharmacological approaches to protect postmenopausal women from the elevated risk of cardiovascular disease.

引用

收藏

页码：1127 / 1134

页数：8

相关论文

共 93 条

[1] MENOPAUSE IS ASSOCIATED WITH A SIGNIFICANT INCREASE IN BLOOD MONOCYTE NUMBER AND A RELATIVE DECREASE IN THE EXPRESSION OF ESTROGEN-RECEPTORS IN HUMAN PERIPHERAL MONOCYTES [J].

BENHUR, H ;

MOR, G ;

INSLER, V ;

BLICKSTEIN, I ;

AMIRZALTSMAN, Y ;

SHARP, A ;

GLOBERSON, A ;

KOHEN, F .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1995, 34 (06) :363-369

[2] Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis [J].

Blasko, Eric ;

Haskell, Christopher A. ;

Leung, Stewart ;

Gualtieri, Giovanna ;

Halks-Miller, Meredith ;

Mahmoudi, Mithra ;

Dennis, Megan K. ;

Prossnitz, Eric R. ;

Karpus, William J. ;

Horuk, Richard .

JOURNAL OF NEUROIMMUNOLOGY, 2009, 214 (1-2) :67-77

[3] Oestrogen treatment of experimental autoimmune encephalomyelitis requires 17β-oestradiol-receptor-positive B cells that up-regulate PD-1 on CD4+ Foxp3+ regulatory T cells [J].

Bodhankar, Sheetal ;

Vandenbark, Arthur A. ;

Offner, Halina .

IMMUNOLOGY, 2012, 137 (04) :282-293

[4] Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells [J].

Bodhankar, Sheetal ;

Wang, Chunhe ;

Vandenbark, Arthur A. ;

Offner, Halina .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (04) :1165-1175

[5]

Bolego C, 2012, CELL S HUM IMM LISB

[6] Selective agonists of estrogen receptor isoforms - New perspectives for cardiovascular disease [J].

Bolego, Chiara ;

Vegeto, Elisabetta ;

Pinna, Christian ;

Maggi, Adriana ;

Cignarella, Andrea .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (10) :2192-2199

[7] PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties [J].

Bouhlel, M. Amine ;

Derudas, Bruno ;

Rigamonti, Elena ;

Dievart, Rebecca ;

Brozek, John ;

Haulon, Stephan ;

Zawadzki, Christophe ;

Jude, Brigitte ;

Torpier, Gerard ;

Marx, Nikolaus ;

Staels, Bart ;

Chinetti-Gbaguidi, Giulia .

CELL METABOLISM, 2007, 6 (02) :137-143

[8] Unlike PPARγ, PPARα or PPARβ/δ activation does not promote human monocyte differentiation toward alternative macrophages [J].

Bouhlel, Mohamed Amine ;

Brozek, John ;

Derudas, Bruno ;

Zawadzki, Christophe ;

Jude, Brigitte ;

Staels, Bart ;

Chinetti-Gbaguidi, Giulia .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 386 (03) :459-462

[9] 17β-estradiol and progesterone do not influence the production of cytokines from lipopolysaccharide-stimulated monocytes in humans [J].

Bouman, A ;

Schipper, M ;

Heineman, MJ ;

Faas, M .

FERTILITY AND STERILITY, 2004, 82 :1212-1219

[10] Sex hormones and the immune response in humans [J].

Bouman, A ;

Heineman, MJ ;

Faas, MM .

HUMAN REPRODUCTION UPDATE, 2005, 11 (04) :411-423

← 1 2 3 4 5 6 7 8 9 10 →