Pharmacogenetics and pharmacogenomics in rheumatology

被引：20

作者：

Szekanecz, Zoltan ^{[1
]}

Mesko, Bertalan ^{[2
]}

Poliska, Szilard ^{[2
]}

Vancsa, Andrea ^{[1
]}

Szamosi, Szilvia ^{[1
]}

Vegh, Edit ^{[1
]}

Simkovics, Enikoe ^{[1
]}

Laki, Judit ^{[3
]}

Kurko, Julia ^{[1
,4
,5
,6
]}

Besenyei, Timea ^{[1
,4
,5
,6
]}

Mikecz, Katalin ^{[4
,5
,6
]}

Glant, Tibor T. ^{[4
,5
,6
]}

Nagy, Laszlo ^{[2
]}

机构：

[1] Univ Debrecen, Med & Hlth Sci Ctr, Dept Rheumatol, Inst Med, H-4032 Debrecen, Hungary

[2] Univ Debrecen, Med & Hlth Sci Ctr, Res Ctr Mol Med, Dept Biochem & Mol Biol, H-4032 Debrecen, Hungary

[3] Natl Hlth Insurance Fund Adm, Dept Med Expertise Clin Auditing & Anal, Budapest, Hungary

[4] Rush Univ, Med Ctr, Sect Mol Med, Dept Orthoped Surg, Chicago, IL 60612 USA

[5] Rush Univ, Med Ctr, Sect Mol Med, Dept Biochem, Chicago, IL 60612 USA

[6] Rush Univ, Med Ctr, Sect Mol Med, Dept Rheumatol, Chicago, IL 60612 USA

来源：

IMMUNOLOGIC RESEARCH | 2013年 / 56卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

Pharmacogenetics; Pharmacogenomics; DMARDs; SNP; Genetic signature; Rheumatoid arthritis; NSAIDs; Biologics; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; TUMOR-NECROSIS-FACTOR; REDUCED FOLATE CARRIER; MULTIDRUG-RESISTANCE GENE; I MDR-I; AUTOIMMUNE DISORDERS; COMMON POLYMORPHISMS; THYMIDYLATE SYNTHASE; A1298C POLYMORPHISM; EXPRESSION PROFILE;

D O I：

10.1007/s12026-013-8405-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pharmacogenetics and pharmacogenomics deal with possible associations of a single genetic polymorphism or those of multiple gene profiles with responses to drugs. In rheumatology, genes and gene signatures may be associated with altered efficacy and/or safety of anti-inflammatory drugs, disease-modifying antirheumatic drugs (DMARDs) and biologics. In brief, genes of cytochrome P450, other enzymes involved in drug metabolism, transporters and some cytokines have been associated with responses to and toxicity of non-steroidal anti-inflammatory drugs, corticosteroids and DMARDs. The efficacy of biologics may be related to alterations in cytokine, chemokine and Fc gamma R genes. Numerous studies reported multiple genetic signatures in association with responses to biologics; however, data are inconclusive. More, focused studies carried out in larger patient cohorts, using pre-selected genes, may be needed in order to determine the future of pharmacogenetics and pharmacogenomics as tools for personalized medicine in rheumatology.

引用

页码：325 / 333

页数：9

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