MicroRNAs in somatic cell reprogramming

被引：36
作者：
Bao, Xichen
Zhu, Xihua
Liao, Baojian
Benda, Christina
Zhuang, Qiang
Pei, Duanqing
Qin, Baoming [1 ]
Esteban, Miguel A.
机构：
[1] Chinese Acad Sci, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China
来源：
CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 02期
基金：
中国国家自然科学基金;
关键词：
PLURIPOTENT STEM-CELLS; NONCODING RNA; HUMAN ES; MOUSE; EXPRESSION; MIR-302; DIFFERENTIATION; GENERATION; TARGETS; GENES;
D O I：
10.1016/j.ceb.2012.12.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The generation of induced pluripotent stem (iPS) cells by exogenous transcription factors involves a comprehensive rearrangement of cellular functions, including the microRNA profile. The resulting cell lines are similar to embryonic stem (ES) cells and have therefore raised much interest for in vitro studies and the perspective of clinical application. Yet, nnicroRNAs are not mere listeners of the reprogramming orchestra but play an active role in the process. In consequence, overexpression or suppression of individual microRNAs has profound effects in colony formation efficiency, and in combination they can produce iPS cells without added transcription factors. Moreover, variations in microRNA expression of iPS/ES cells can predict their differentiation potential and may have consequences at other levels. Altogether, these findings highlight the relevance of pursuing further these studies.
引用
收藏
页码：208 / 214
页数：7
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