The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

被引:649
作者
Pages, Jean-Marie [1 ]
James, Chloe E. [1 ]
Winterhalter, Mathias [2 ]
机构
[1] Univ Mediterranee, Fac Med & Harmacie, UMR MD Transporteurs Membranaires Chimioresistanc, F-13385 Marseille, France
[2] Jacobs Univ Bremen, Sch Sci & Engn, D-28759 Bremen, Germany
关键词
D O I
10.1038/nrmicro1994
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Gram-negative bacteria are responsible for a large proportion of antibiotic-resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm. The outer membrane contains various protein channels, called porins, which are involved in the influx of various compounds, including several classes of antibiotics. Bacterial adaptation to reduce influx through porins is an increasing problem worldwide that contributes, together with efflux systems, to the emergence and dissemination of antibiotic resistance. An exciting challenge is to decipher the genetic and molecular basis of membrane impermeability as a bacterial resistance mechanism. This Review outlines the bacterial response towards antibiotic stress on altered membrane permeability and discusses recent advances in molecular approaches that are improving our knowledge of the physico-chemical parameters that govern the translocation of antibiotics through porin channels.
引用
收藏
页码:893 / 903
页数:11
相关论文
共 92 条
  • [1] Effect of two polyamine toxins on the bacterial porin OmpF
    Baslé, A
    Delcour, AH
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 285 (02) : 550 - 554
  • [2] Crystal structure of osmoporin OmpC from E-coli at 2.0 Å
    Basle, Arnaud
    Rummel, Gabriele
    Storici, Paola
    Rosenbusch, Juerg P.
    Schirmer, Tilman
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2006, 362 (05) : 933 - 942
  • [3] Molecular transport through channels and pores: Effects of in-channel interactions and blocking
    Bauer, Wolfgang R.
    Nadler, Walter
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (31) : 11446 - 11451
  • [4] Optimizing transport of metabolites through large channels: Molecular sieves with and without binding
    Berezhkovskii, AM
    Bezrukov, SM
    [J]. BIOPHYSICAL JOURNAL, 2005, 88 (03) : L17 - L19
  • [5] Diffusion model of solute dynamics in a membrane channel: Mapping onto the two-site model and optimizing the flux
    Bezrukov, Sergey M.
    Berezhkovskii, Alexander M.
    Szabo, Attila
    [J]. JOURNAL OF CHEMICAL PHYSICS, 2007, 127 (11)
  • [6] Examining noise sources at the single-molecule level:: 1/f noise of an open maltoporin channel
    Bezrukov, SM
    Winterhalter, M
    [J]. PHYSICAL REVIEW LETTERS, 2000, 85 (01) : 202 - 205
  • [7] Structural insight into OprD substrate specificity
    Biswas, Shyamasri
    Mohammad, M. Mohammad
    Patel, Dimki R.
    Movileanu, Liviu
    van den Berg, Bert
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (11) : 1108 - 1109
  • [8] Measuring the impact of multidrug resistance in nosocomial infection
    Blot, Stijn
    Depuydt, Pieter
    Vandewoude, Koenraad
    De Bacquer, Dirk
    [J]. CURRENT OPINION IN INFECTIOUS DISEASES, 2007, 20 (04) : 391 - 396
  • [9] Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes
    Bornet, C
    Chollet, R
    Malléa, M
    Chevalier, J
    Davin-Regli, A
    Pagès, JM
    Bollet, C
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (04) : 985 - 990
  • [10] Imipenem resistance of Enterobacter aerogenes mediated by outer membrane permeability
    Bornet, C
    Davin-Regli, A
    Bosi, C
    Pages, JM
    Bollet, C
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (03) : 1048 - 1052