共 92 条
The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
被引:649
作者:

Pages, Jean-Marie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Mediterranee, Fac Med & Harmacie, UMR MD Transporteurs Membranaires Chimioresistanc, F-13385 Marseille, France Univ Mediterranee, Fac Med & Harmacie, UMR MD Transporteurs Membranaires Chimioresistanc, F-13385 Marseille, France

James, Chloe E.
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h-index: 0
机构:
Univ Mediterranee, Fac Med & Harmacie, UMR MD Transporteurs Membranaires Chimioresistanc, F-13385 Marseille, France Univ Mediterranee, Fac Med & Harmacie, UMR MD Transporteurs Membranaires Chimioresistanc, F-13385 Marseille, France

Winterhalter, Mathias
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h-index: 0
机构:
Jacobs Univ Bremen, Sch Sci & Engn, D-28759 Bremen, Germany Univ Mediterranee, Fac Med & Harmacie, UMR MD Transporteurs Membranaires Chimioresistanc, F-13385 Marseille, France
机构:
[1] Univ Mediterranee, Fac Med & Harmacie, UMR MD Transporteurs Membranaires Chimioresistanc, F-13385 Marseille, France
[2] Jacobs Univ Bremen, Sch Sci & Engn, D-28759 Bremen, Germany
关键词:
D O I:
10.1038/nrmicro1994
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Gram-negative bacteria are responsible for a large proportion of antibiotic-resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm. The outer membrane contains various protein channels, called porins, which are involved in the influx of various compounds, including several classes of antibiotics. Bacterial adaptation to reduce influx through porins is an increasing problem worldwide that contributes, together with efflux systems, to the emergence and dissemination of antibiotic resistance. An exciting challenge is to decipher the genetic and molecular basis of membrane impermeability as a bacterial resistance mechanism. This Review outlines the bacterial response towards antibiotic stress on altered membrane permeability and discusses recent advances in molecular approaches that are improving our knowledge of the physico-chemical parameters that govern the translocation of antibiotics through porin channels.
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页码:893 / 903
页数:11
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