A novel method for PEGylation of chitosan nanoparticles through photopolymerization

被引：14

作者：

Bozuyuk, Ugur ^{[1
,2
]}

Gokulu, Ipek S. ^{[1
]}

Dogan, Nihal Olcay ^{[1
]}

Kizilel, Seda ^{[1
]}

机构：

[1] Koc Univ, Chem & Biol Engn, TR-34450 Istanbul, Turkey

[2] Max Planck Inst Intelligent Syst, Phys Intelligence Dept, Heisenbergstr 3, D-70569 Stuttgart, Germany

来源：

RSC ADVANCES | 2019年 / 9卷 / 25期

关键词：

DRUG-DELIVERY; HYDROGELS; CHEMISTRY; CHITIN;

D O I：

10.1039/c9ra00780f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized through altered PEG chain length, concentration and duration of UV exposure. The method developed here has potential for clinical translation of chitosan nanoparticles. It also allows for the scalable and fast synthesis of nanoparticles with colloidal stability.

引用

页码：14011 / 14015

页数：5

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