Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions

被引：181

作者：

Russo, Alessandra ^{[1
]}

Formisano, Carmen ^{[2
]}

Rigano, Daniela ^{[2
]}

Senatore, Felice ^{[2
]}

Delfine, Sebastiano ^{[3
]}

Cardile, Venera ^{[4
]}

Rosselli, Sergio ^{[5
]}

Bruno, Maurizio ^{[5
]}

机构：

[1] Univ Catania, Biochem Sect, Dept Drug Sci, I-95125 Catania, Italy

[2] Univ Naples Federico II, Dept Chem Nat Cpds, I-80131 Naples, Italy

[3] Univ Molise, Dept SAVA, I-86100 Campobasso, Italy

[4] Univ Catania, Dept Physiol Sci, I-95125 Catania, Italy

[5] Univ Palermo, Sect Organ Chem, Dept Mol & Biomol Sci & Technol STEMBIO, I-90128 Palermo, Italy

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 55卷

关键词：

Salvia officinalis; Essential oil; alpha-Thujone; beta-Thujone; Camphor; Anticancer; CANCER-CELL LINES; LUNG-CANCER; INDUCED APOPTOSIS; BETA-ELEMENE; DNA-DAMAGE; A549; CELLS; ACTIVATION; STRESS; PLANTS; LYMPHOCYTES;

D O I：

10.1016/j.fct.2012.12.036

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Salvia officinalis L can be found worldwide and its leaves are commonly used as ingredient in food industry. Sage essential oil is applied in the treatment of a range of diseases and has been shown to possess different biological activities. The objectives of our research were to study the effects of environment on crop, chemical composition and anticancer activity on S. officinalis essential oil. Sage was cultivated at eighteen experimental sites in south-central Italy (Molise) in different growing environments. The essential oils (S1-S18), extracted by hydrodistillation, were analyzed by GC and CG/MS. Results show that the main components were alpha-thujone, camphor, borneol, gamma-muurolene and sclareol for all the samples, but the percentages of these compounds varied depending on environmental factors such as altitude, water availability and pedo-climatic conditions. The growth-inhibitory and proapoptotic effects of the eighteen sage essential oils were evaluated in three human melanoma cell lines, A375, M14, and A2058. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：42 / 47

页数：6

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