Kv1.5 in the immune system: the good, the bad, or the ugly?

被引：15

作者：

Felipe, Antonio ^{[1
]}

Soler, Concepcio ^{[2
]}

Comes, Nuria ^{[1
]}

机构：

[1] Univ Barcelona, Inst Biomed, Dept Bioquim & Biol Mol, Mol Physiol Lab, E-08028 Barcelona, Spain

[2] Univ Barcelona, Fac Med, Dept Patol & Terapeut Expt, E-08028 Barcelona, Spain

来源：

FRONTIERS IN PHYSIOLOGY | 2010年 / 1卷

关键词：

leukocytes; potassium channels; association; heterotetramers; channelosome; GATED POTASSIUM CHANNELS; DEPENDENT K+ CHANNEL; ION CHANNELS; IMMUNOLOGICAL SYNAPSE; FUNCTIONAL EXPRESSION; PLASMA-MEMBRANE; MOLECULAR-BASIS; VOLTAGE; MACROPHAGES; CURRENTS;

D O I：

10.3389/fphys.2010.00152

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

For the last 20 years, knowledge of the physiological role of voltage-dependent potassium channels (Kv) in the immune system has grown exponentially. Leukocytes express a limited repertoire of Kv channels, which contribute to the membrane potential. These proteins are involved in the immune response and are therefore considered good pharmacological targets. Although there is a clear consensus about the physiological relevance of Kv1.3, the expression and the role of Kv1.5 are controversial. However, recent reports indicate that certain heteromeric Kv1.3/Kv1.5 associations may provide insight on Kv1.5. Here, we summarize what is known about this issue and highlight the role of Kv1.5 partnership interactions that could be responsible for this debate. The Kv1.3/Kv1.5 heterotetrameric composition of the channel and their possible differential associations with accessory regulatory proteins warrant further investigation.

引用

页数：8

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