Azole cross-resistance in Aspergillus fumigatus

被引：93

作者：

Mosquera, J

Denning, DW

机构：

[1] Wythenshawe Hosp, Educ & Res Ctr, Dept Med, Manchester M29 9LT, Lancs, England

[2] Univ Manchester, Sch Med, Manchester M13 9PT, Lancs, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 02期

关键词：

D O I：

10.1128/AAC.46.2.556-557.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We susceptibility tested 17 clinical isolates of Aspergillus fumigates, for most of which MICs of itraeonazole were elevated (MIC at which 50% of the isolates tested are inhibited, 16 mug/ml), against itraconazole, posaconazole, ravuconazole, and voriconazole. Posaconazole was the most active against itraconazole-susceptible isolates. A complex pattern of cross-resistance and hypersusceptibility was seen with voriconazole and ravuconazole, suggesting marked differences in activity and mechanisms of resistance.

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页码：556 / 557

页数：2

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