Neonatal Alloimmune Thrombocytopenia Associated with Massive Chronic Intervillositis: A Case Report and Review of the Literature

被引：11

作者：

Tchakarov, Amanda ^{[1
]}

Coffey, Amy ^{[2
]}

Tatevian, Nina ^{[1
]}

机构：

[1] Univ Texas Med Sch Houston, Dept Pathol & Lab Med, Houston, TX USA

[2] Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA

来源：

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | 2013年 / 16卷 / 01期

关键词：

maternal antibodies; placental alloimmunization; platelet destruction;

D O I：

10.2350/12-08-1246-CR.1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Neonatal alloimmune thrombocytopenia (NAIT) presents as isolated thrombocytopenia in a normal neonate as a result of destruction of fetal platelets by maternal antibodies against paternally derived human platelet antigens. Neonatal alloimmune thrombocytopenia affects 0.1% of births, with maternal antibodies crossing the placenta as early as 14 weeks' gestation. Few reports describe placental histopathological changes occurring in NAIT cases. We present a case of NAIT associated with massive chronic intervillositis, a rare entity occurring in 0.06% to 0.8% of reviewed 2nd- and 3rd-trimester placentas; to our knowledge, this is the 1st report of such an association.

引用

页码：32 / 34

页数：3

共 10 条

[1] Chronic villitis in untreated neonatal alloimmune thrombocytopenia: An etiology for severe early intrauterine growth restriction and the effect of intravenous immunoglobulin therapy [J].

Althaus, J ;

Weir, EG ;

Askin, F ;

Kickler, TS ;

Blakemore, K .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2005, 193 (03) :1100-1104

[2] Chronic histiocytic intervillositis: A placental lesion associated with recurrent reproductive loss [J].

Boyd, TK ;

Redline, RW .

HUMAN PATHOLOGY, 2000, 31 (11) :1389-1396

[3] Human platelet antigen-specific alloantibodies implicated in 1162 cases of neonatal alloimmune thrombocytopenia [J].

Davoren, A ;

Curtis, BR ;

Aster, RH ;

McFarland, JG .

TRANSFUSION, 2004, 44 (08) :1220-1225

[4] MASSIVE CHRONIC INTERVILLOSITIS ASSOCIATED WITH RECURRENT ABORTIONS [J].

DOSS, BJ ;

GREENE, MF ;

HILL, J ;

HEFFNER, LJ ;

BIEBER, FR ;

GENEST, DR .

HUMAN PATHOLOGY, 1995, 26 (11) :1245-1251

[5] Neonatal alloimmune thrombocytopenia [J].

Kaplan, Cecile .

HAEMATOLOGICA, 2008, 93 (06) :805-807

[6] Ultrastructural localization of glycoprotein IIIa (GPIIIa, β3 integrin) on placental syncytiotrophoblast microvilli: implications for platelet alloimmunization during pregnancy [J].

Kumpel, Belinda M. ;

Sibley, Karin ;

Jackson, David J. ;

White, Graham ;

Soothill, Peter W. .

TRANSFUSION, 2008, 48 (10) :2077-2086

[7] Chronic histiocytic intervillositis of unknown etiology: Clinical features in a consecutive series of 69 cases [J].

Marchaudon, V. ;

Devisme, L. ;

Petit, S. ;

Ansart-Franquet, H. ;

Vaast, P. ;

Subtil, D. .

PLACENTA, 2011, 32 (02) :140-145

[8] Chronic intervillositis of unknown etiology (CIUE): Relation between placental lesions and perinatal outcome [J].

Parant, Olivier ;

Capdet, Jerome ;

Kessler, Sylvie ;

Aziza, Jacqueline ;

Berrebi, Alain .

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2009, 143 (01) :9-13

[9]

Rota C, 2006, J Gynecol Obstet Biol Reprod (Paris), V35, P711

[10]

Skogen B, 2010, EXPERT REV HEMATOL, V3, P559, DOI [10.1586/ehm.10.49, 10.1586/EHM.10.49]

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