New Concepts in the Pathogenesis of Sjogren's Syndrome

被引：62
作者：
Delaleu, Nicolas [1 ]
Jonsson, Malin V. [1 ,2 ]
Appel, Silke [1 ]
Jonsson, Roland [1 ,3 ,4 ]
机构：
[1] Univ Bergen, Gade Inst, Broegelmann Res Lab, N-5021 Bergen, Norway
[2] Univ Bergen, Inst Med, Rheumatol Sect, N-5021 Bergen, Norway
[3] Haukeland Hosp, Dept Rheumatol, N-5021 Bergen, Norway
[4] Haukeland Hosp, Dept Otolaryngol Head & Neck Surg, N-5021 Bergen, Norway
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2008年 / 34卷 / 04期
关键词：
Sjogren's syndrome; Etiology; Pathogenesis; IFN-alpha; B cells; Biomarkers;
D O I：
10.1016/j.rdc.2008.08.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sjogren's syndrome (SS) is a rheumatic disease in which the salivary and lacrimal glands are the principal targets of a pathologic autoimmune reaction. SS is manifested by xerostemia and keratoconjunctivitis sicca and marked by persistent focal mononuclear cell infiltration within the salivary glands, often accompanied by glandular atrophy and fibrosis. A challenge is to clarify the roles of genetic backgrounds and environmental trigger. Advanced bioanalytic platforms have enabled identification of potential biomarkers with the intent to improve diagnosis, promote development of prognostic tools, and identify processes for therapeutic treatment. Such approaches allow a glimpse at the apparent complexity of SS.
引用
收藏
页码：833 / +
页数：14
相关论文
共 94 条
[31]   Sjogren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease [J].
Gao, JH ;
Killedar, S ;
Cornelius, JG ;
Nguyen, C ;
Cha, SH ;
Peck, AB .
JOURNAL OF AUTOIMMUNITY, 2006, 26 (02) :90-103
[32]   CTLA-4+49A/G and CT60 gene polymorphisms in primary Sjogren syndrome [J].
Gottenberg, Jacques-Eric ;
Loiseau, Pascale ;
Azarian, Mariam ;
Chen, Chun ;
Cagnard, Nicolas ;
Hachulla, Eric ;
Puechal, Xavier ;
Sibilia, Jean ;
Charron, Dominique ;
Mariette, Xavier ;
Miceli-Richard, Corinne .
ARTHRITIS RESEARCH & THERAPY, 2007, 9 (02)
[33]   Failure to confirm coxsackievirus infection in primary Sjogren's syndrome [J].
Gottenberg, Jacques-Eric ;
Pallier, Coralie ;
Ittah, Marc ;
Lavie, Frederic ;
Miceli-Richard, Corinne ;
Sellam, Jeremie ;
Nordmann, Patrice ;
Cagnard, Nicolas ;
Sibilia, Jean ;
Mariette, Xavier .
ARTHRITIS AND RHEUMATISM, 2006, 54 (06) :2026-2028
[34]   Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome [J].
Gottenberg, JE ;
Cagnard, N ;
Lucchesi, C ;
Letourneur, F ;
Mistou, S ;
Lazure, T ;
Jacques, S ;
Ba, N ;
Ittah, M ;
Lepajolec, C ;
Labetoulle, M ;
Ardizzone, M ;
Sibilia, J ;
Fournier, C ;
Chiocchia, G ;
Mariette, X .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :2770-2775
[35]   CD4 CD25high regulatory T cells are not impaired in patients with primary Sjogren's syndrome [J].
Gottenberg, JE ;
Lavie, F ;
Abbed, K ;
Gasnault, J ;
Le Nevot, E ;
Delfraissy, JF ;
Taoufik, Y ;
Mariette, X .
JOURNAL OF AUTOIMMUNITY, 2005, 24 (03) :235-242
[36]   Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjogren's syndrome [J].
Gottenberg, JE ;
Mignot, S ;
Nicaise-Rolland, P ;
Cohen-Solal, J ;
Aucouturier, F ;
Goetz, J ;
Labarre, C ;
Meyer, O ;
Sibilia, J ;
Mariette, X .
ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (01) :114-117
[37]   EXOCRINOPATHY RESEMBLING SJOGRENS SYNDROME IN HTLV-1 TAX TRANSGENIC MICE [J].
GREEN, JE ;
HINRICHS, SH ;
VOGEL, J ;
JAY, G .
NATURE, 1989, 341 (6237) :72-74
[38]   Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome [J].
Groom, J ;
Kalled, SL ;
Cutler, AH ;
Olson, C ;
Woodcock, SA ;
Schneider, P ;
Tschopp, J ;
Cachero, TG ;
Batten, M ;
Wheway, J ;
Mauri, D ;
Cavill, D ;
Gordon, TP ;
Mackay, CR ;
Mackay, F .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (01) :59-68
[39]   LYMPHOCYTIC SIALADENITIS OF SJOGRENS-SYNDROME ASSOCIATED WITH CHRONIC HEPATITIS-C VIRUS LIVER-DISEASE [J].
HADDAD, J ;
DENY, P ;
MUNZGOTHEIL, C ;
AMBROSINI, JC ;
TRINCHET, JC ;
PATERON, D ;
MAL, F ;
CALLARD, P ;
BEAUGRAND, M .
LANCET, 1992, 339 (8789) :321-323
[40]   Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjogren's syndrome [J].
Harangi, M ;
Kaminski, WE ;
Fleck, M ;
Orsó, E ;
Zeher, M ;
Kiss, E ;
Szekanecz, Z ;
Zilahi, E ;
Marienhagen, J ;
Aslanidis, C ;
Paragh, G ;
Bolstad, AI ;
Jonsson, R ;
Schmitz, G .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (01) :305-317
12345678910