Antihypertensive Medications and Their Effects on Lipid Metabolism

被引:20
|
作者
Deshmukh, Mrunalini [1 ]
Lee, Ho Won [1 ]
McFarlane, Samy I. [1 ]
Whaley-Connell, Adam [1 ]
机构
[1] SUNY Hlth Sci Ctr, Dept Med, Kings Cty Hosp Ctr, Brooklyn, NY 11203 USA
关键词
D O I
10.1007/s11892-008-0037-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hypertension and hyperlipidemia are interrelated and share common pathophysiologic mechanisms, such as insulin resistance and endothelial dysfunction. Accumulating evidence shows that it is important to regulate hypertension and hyperlipidemia to reduce cardiovascular risk. However, medications such as beta-blockers and thiazide diuretics, which are widely used for blood pressure regulation, are known to have several metabolic side effects. Despite deleterious effects on glucose metabolism and lipid metabolism, these medications have been proven to reduce cardiovascular risk. On the other hand, calcium channel blockers, angiotensin-converting enzyme inhibitors, and alpha-blockers have either no effect or favorable effects on the lipid profile. This review outlines the need to control hypertension, options for several anti hypertensive medications, their differing effects on lipid metabolism, and the clinical implications of their effects on lipid parameters.
引用
收藏
页码:214 / 220
页数:7
相关论文
共 50 条
  • [1] Antihypertensive medications and their effects on lipid metabolism
    Mrunalini Deshmukh
    Ho Won Lee
    Samy I. McFarlane
    Adam Whaley-Connell
    Current Diabetes Reports, 2008, 8 : 214 - 220
  • [2] Lipid Effects of Antihypertensive Medications
    Deano, Roderick
    Sorrentino, Matthew
    CURRENT ATHEROSCLEROSIS REPORTS, 2012, 14 (01) : 70 - 77
  • [3] Lipid Effects of Antihypertensive Medications
    Roderick Deano
    Matthew Sorrentino
    Current Atherosclerosis Reports, 2012, 14 : 70 - 77
  • [4] EFFECTS OF ANTIHYPERTENSIVE MEDICATIONS ON CARBOHYDRATE-METABOLISM
    MOLITCH, ME
    HOU, SH
    GOTTESMAN, S
    KAPCALA, LP
    KOPELMAN, RI
    MADIAS, NE
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1986, 39 (03): : 398 - 407
  • [5] Effects of antihypertensive therapy on glucose and lipid metabolism
    Zehetgruber, M
    Christ, G
    Mundigler, G
    Gabriel, H
    Huber, K
    WIENER KLINISCHE WOCHENSCHRIFT, 1996, 108 (24) : 775 - 780
  • [6] EFFECTS OF ANTIHYPERTENSIVE DRUGS ON LIPID-METABOLISM
    LEREN, P
    CLINICAL THERAPEUTICS, 1987, 9 (03) : 326 - 332
  • [7] Effects of antipsychotic medications on weight and lipid and glucose metabolism
    Verma, S. K.
    Poon, L. Y.
    Chan, Y. H.
    Chong, S. A.
    SCHIZOPHRENIA RESEARCH, 2006, 86 : S129 - S130
  • [8] The Glycemic Effects of Antihypertensive Medications
    Barzilay, Joshua I.
    Davis, Barry R.
    Whelton, Paul K.
    CURRENT HYPERTENSION REPORTS, 2014, 16 (01)
  • [9] The Glycemic Effects of Antihypertensive Medications
    Joshua I. Barzilay
    Barry R. Davis
    Paul K. Whelton
    Current Hypertension Reports, 2014, 16
  • [10] NEUROBEHAVIORAL EFFECTS OF ANTIHYPERTENSIVE MEDICATIONS
    MULDOON, MF
    MANUCK, SB
    SHAPIRO, AP
    WALDSTEIN, SR
    JOURNAL OF HYPERTENSION, 1991, 9 (06) : 549 - 559