Epidemiological and virological characterization of a large community-wide outbreak of hepatitis A in Southern Italy

被引：35
作者：
Pontrelli, G. [1 ,2 ]
Boccia, D. [3 ]
Di Renzi, M. [3 ]
Massari, M. [1 ]
Giugliano, F. [5 ]
Celentano, L. Pastore [1 ]
Taffon, S. [4 ]
Genovese, D. [4 ]
Di Pasquale, S. [6 ]
Scalise, F. [6 ]
Rapicetta, M. [4 ]
Croci, L. [6 ]
Salmaso, S. [1 ]
机构：
[1] Ist Super Sanita, Ctr Nazl Epidemiol Sorveglianza & Promoz Salute, I-00161 Rome, Italy
[2] Univ Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, I-00161 Rome, Italy
[3] Swedish Inst Communicable Dis, European Programme Intervent Epidemiol Training, EPIET, Stockholm, Sweden
[4] Ist Super Sanita, Dipartimento Malattie Infett Parassitarie & Immun, I-00161 Rome, Italy
[5] Serv Epidemiol & Prevenz, Naples, Italy
[6] Ist Super Sanita, Ctr Nazl Qualita Alimenti & Rischi Alimentari, I-00161 Rome, Italy
来源：
EPIDEMIOLOGY AND INFECTION | 2008年 / 136卷 / 08期
关键词：
D O I：
10.1017/S095026880700951X
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
A large outbreak of hepatitis A virus (HAV) infection occurred in 2004 in Campania, a region of southern Italy, with 882 cases reported between 1 January and 1 August. The local public health authorities and the Italian National Institute of Health carried out Investigations in order to characterize the agent, identify the source of infection and the route of transmission, and implement appropriate control measures. A web-based reporting system enhanced the flow of information between public health authorities, providing real-time epidemic curves and frequency distributions. The same 1B HAV genotype wits found in 90 % of sera from a subset of patients with acute disease, suggesting a local common source. A case-control study in the municipality with the highest attack rate showed that raw seafood consumption, in particular if illegally sold in water, was strongly associated with HAV illness. Samples of seafood systematically collected from retailers were found contaminated by HAV.
引用
收藏
页码：1027 / 1034
页数：8
相关论文
共 14 条
[1]   Outbreak of infection with hepatitis a virus (HAV) associated with a foodhandler and confirmed by sequence analysis reveals a new HAV genotype IB variant [J].
Chironna, M ;
Lopalco, P ;
Prato, R ;
Germinario, C ;
Barbuti, S ;
Quarto, M .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (06) :2825-2828
[2]   Genetic analysis of hepatitis A virus outbreak in France confirms the co-circulation of subgenotypes Ia, Ib and reveals a new genetic lineage [J].
Costa-Mattioli, M ;
Monpoeho, S ;
Schvoerer, C ;
Besse, B ;
Aleman, MH ;
Billaudel, S ;
Cristina, J ;
Ferré, V .
JOURNAL OF MEDICAL VIROLOGY, 2001, 65 (02) :233-240
[3]   Closed-circuit system for the depuration of mussels experimentally contaminated with hepatitis A virus [J].
De Medici, D ;
Ciccozzi, M ;
Fiore, A ;
Di Pasquale, S ;
Parlato, A ;
Ricci-Bitti, P ;
Croci, L .
JOURNAL OF FOOD PROTECTION, 2001, 64 (06) :877-880
[4]   Characterization of hepatitis A virus isolates from subgenotypes IA and IB in Rio de Janeiro, Brazil [J].
de Paula, VS ;
Baptista, ML ;
Lampe, E ;
Niel, C ;
Gaspar, AMC .
JOURNAL OF MEDICAL VIROLOGY, 2002, 66 (01) :22-27
[5]  
Fiore Anthony E., 2006, Morbidity and Mortality Weekly Report, V55, P1
[6]   Viruses and bivalve shellfish [J].
Lees, D .
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2000, 59 (1-2) :81-116
[7]  
Lopalco P.L., 1997, Euro Surveill, V2, P31
[8]   Hepatitis A and B in children and adolescents -: what can we learn from Puglia (Italy) and Catalonia (Spain)? [J].
Lopalco, PL ;
Salleras, L ;
Barbuti, S ;
Germinario, C ;
Bruguera, M ;
Buti, M ;
Domínguez, A .
VACCINE, 2000, 19 (4-5) :470-474
[9]  
Malfait P, 1996, Euro Surveill, V1, P33
[10]   Incidence of and risk factors for hepatitis A in Italy: Public health indications from a 10-year surveillance [J].
Mele, A ;
Stroffolini, T ;
Palumbo, F ;
Gallo, G ;
Ragni, P ;
Balocchini, E ;
Tosti, ME ;
Corona, R ;
Marzolini, A ;
Moiraghi, A .
JOURNAL OF HEPATOLOGY, 1997, 26 (04) :743-747
12