Dual responsive zein hydrogel membrane with selective protein adsorption and sustained release property

被引：35
作者：
Qi, Hualei [1 ,2 ]
Cao, Jialin [1 ]
Xin, Yanjiao [1 ]
Mao, Xuan [1 ]
Xie, Deming [1 ]
Luo, Jianjun [1 ]
Chu, Bin [3 ]
机构：
[1] Jinan Univ, Coll Life Sci & Technol, Key Lab Biomat Guangdong Higher Educ Inst, Dept Biomed Engn, Guangzhou 510632, Guangdong, Peoples R China
[2] Zhejiang Univ, Inst Energy Engn, Hangzhou 310007, Zhejiang, Peoples R China
[3] Tsinghua Univ, Res Inst, Key Lab Biomed Mat & Implants, Shenzhen 518057, Peoples R China
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 70卷
关键词：
Zein; Hydrogel; Membrane; Stimuli-responsive; Drug delivery; ALGINATE HYDROGEL; DRUG-DELIVERY; CROSS-LINKING; ACID; SCAFFOLDS; FILMS; PHOSPHORYLATION; ENCAPSULATION; DEGRADATION; STABILITY;
D O I：
10.1016/j.msec.2016.09.010
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Drug-loaded hydrogels have been paid increasing attentions in biomedical fields. As a sort of natural plant protein, zein generally cannot form hydrogel with high water retention because of its predominant hydrophobicity, which will limit its application as biomaterial. In this paper, zein electrospun fibrous membranes (ZEFM) are fabricated through a chemical modification of zein using citric acid and acetic anhydride. The resulting ZEFM can be totally soluble in neutral phosphate buffer solution. After being crosslinked by sodium hexametaphosphate, the ZEFM can form a hydrogel membrane and displays stimuli-responsive behavior towards pH and ionic strength. The hydrogel membrane exhibits better protein adsorption, selectivity and sustained release profile for positively-charged proteins such as cytochrome C, compared with those unmodified ones, and also shows fast biodegradation behavior and qualified cytotoxicity, which all make it favourable for biomedical use. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：347 / 356
页数：10
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