Organocatalyzed Enantioselective Desymmetrization of Diols in the Preparation of Chiral Building Blocks

被引：83

作者：

Diaz-de-Villegas, Maria D. ^{[1
]}

Galvez, Jose A. ^{[1
]}

Badorrey, Ramon ^{[1
]}

Lopez-Ram-de-Viu, M. Pilar ^{[1
]}

机构：

[1] Univ Zaragoza, Dept Catalisis & Proc Catalit, ISQCH, CSIC, E-50009 Zaragoza, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 44期

关键词：

asymmetric catalysis; desymmetrization; diols; enantioselectivity; organocatalysis; CATALYTIC ASYMMETRIC PHOSPHORYLATION; HIGHLY EFFICIENT; ACYL-TRANSFER; KINETIC RESOLUTION; MESO-DIOLS; TWISTED AMIDES; ACYLATION; ALCOHOLS; DERIVATIVES; DMAP;

D O I：

10.1002/chem.201202264

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Desymmetrization of diols is a powerful tool to the synthesis of chiral building blocks. Among the different approaches to perform discrimination between both enantiotopic hydroxyl groups, the organocatalytic approach has gained importance in the last years. A diverse range of organocatalysts has been used to efficiently promote this enantioselective transformation and this Minireview examines the different contributions in this field.

引用

页码：13920 / 13935

页数：16

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