LncRNA OIP5-AS1 predicts poor prognosis and regulates cell proliferation and apoptosis in bladder cancer

被引：34

作者：

Wang, Yang ^{[1
]}

Shi, Fu ^{[2
]}

Xia, Yong ^{[1
]}

Zhao, Huacai ^{[3
]}

机构：

[1] Hanzhong Cent Hosp, Dept Urol, Hangzhong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Urol, Shenzhen, Peoples R China

[3] Xi An Jiao Tong Univ, Affiliated Hosp 3, Shaanxi Prov Peoples Hosp, Dept Urol, 256 Youyi Rd West, Xian 710068, Shaanxi, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 05期

关键词：

biomarker; bladder cancer; long noncoding RNA; Opa-interacting protein 5 antisense RNA 1; Opa-interacting protein 5; NONCODING RNA OIP5-AS1; INHIBITS PROLIFERATION; STATISTICS; EXPRESSION; KNOCKDOWN; ONCOGENE;

D O I：

10.1002/jcb.28024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Opa-interacting protein 5 antisense RNA 1 (OIP5-AS1) is a long intergenic noncoding RNA, which has been suggested to be dysregulated in human cancers and served as tumor suppressor or promoter depending on tumor types. However, the role of OIP5-AS1 in bladder cancer was still unknown. In our study, OIP5-AS1 was overexpressed in bladder cancer, and associated with clinical progression and short overall survival. The loss-of-function studies suggested downregulation of OIP5-AS1 expression decreased cell viability, induced cell-cycle arrest and promoted cell apoptosis in bladder cancer. There was a positive association between OIP5-AS1 expression and OIP5 expression in bladder cancer tissues. Moreover, downregulation of OIP5-AS1 expression reduced messenger RNA and protein levels of OIP5 in bladder cancer cell lines. In conclusion, OIP5-AS1 is a useful biomarker for predicting clinical progression and poor prognosis and promotes cell proliferation through modulating OIP5 expression.

引用

页码：7499 / 7505

页数：7

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