The new Schiff bases of 2-alkylthio-5-(4-aminophenyl)-1,3,4-oxadiazoles and their antimicrobial activity

被引:2
作者
Ismailova, D. S. [1 ]
Ziyaev, A. A. [1 ]
Bobakulov, Kh. M. [1 ]
Sasmakov, S. A. [1 ]
Makhmudov, U. S. [1 ]
Yusupova, E. G. [1 ]
Azimova, Sh. S. [1 ]
机构
[1] Acad Sci Uzbek, Acad S Yu Yunusov Inst Chem Plant Subst, 77 M Ulugbek Str, Tashkent 100170, Uzbekistan
关键词
5-(4-Aminophenyl)-1,3,4-oxadiazol-2-thione; Aromatic aldehyde; Amino group; NMR spectra; X-ray analysis; Antimicrobial activity; DERIVATIVES;
D O I
10.1007/s13738-018-1530-9
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
By the reaction of 5-(4-aminophenyl)-1,3,4-oxadiazolin-2-thione with alkyl halides 2-alkylthio-5-(4-aminophenyl)-1,3,4-oxadiazoles, 2-4 were obtained. By the reaction of compounds 2-4 with aromatic aldehydes, new Schiff bases 5a-d and 6a-d were synthesized. The structures of synthesized compounds are confirmed by the IR, UV, H-1 NMR for all compounds, C-13 NMR for compounds 3, 4, 5a-5d, 6a, 6d and X-ray for compound 3. All substances were tested in vitro for their antibacterial and antifungal activity. The results showed that Compound 2 exhibited remarkable activity against Candida albicans. Compounds 5a-d were found to exhibit a weak selective activity against Gram-positive bacteria of Bacillus subtilis and compounds 6a-d against Gram-negative bacteria of Escherichia coli.
引用
收藏
页码:545 / 551
页数:7
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