Lacosamide in the treatment of epilepsy

被引：0
作者：
Petrukhin, A. S. [1 ]
Voronkova, K. V.
Pylayeva, O. A.
机构：
[1] Pirogov Russian Natl Res Med Univ, Moscow, Russia
来源：
ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2012年 / 112卷 / 06期
关键词：
treatment of epilepsy; lacosamide; peroral form; intravenous form; PARTIAL-ONSET SEIZURES; NONCONVULSIVE STATUS EPILEPTICUS; INTRAVENOUS LACOSAMIDE; ORAL LACOSAMIDE; ADJUNCTIVE THERAPY; SAFETY; EFFICACY; REPLACEMENT; UTILITY; ADULTS;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The new antiepileptic drug (AED) lacosamide (vimpat, "UCB Pharma") with a new mechanism of action was registered in Russia in 2010. The drug should be used as add-on treatment in patients over 16 years and older with non-controlled focal seizures with- or without secondary localization. The authors review the data of literature and the results of trials on efficacy and safety of lacosamide for peroral and intravenous introduction. Randomized clinical trials of the peroral form of this drug provide evidence that lacosamide is a prospective preparation for complex treatment of drug-resistant epilepsy in the view of its safety and tolerability. The availability of the infusion form is advantageous compared to other AED making it possible to continue treatment in cases when the peroral intake of AED is temporary impossible.
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页码：65 / 71
页数：7
相关论文
共 49 条
[1]   Intravenous lacosamide-An effective add-on treatment of refractory status epilepticus [J].
Albers, Johannes Michael ;
Moeddel, Gabriel ;
Dittrich, Ralf ;
Steidl, Corinna ;
Suntrup, Sonja ;
Ringelstein, Erich Bernd ;
Dziewas, Rainer .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2011, 20 (05) :428-430
[2]   Second-line status epilepticus treatment: Comparison of phenytoin, valproate, and levetiracetam [J].
Alvarez, Vincent ;
Januel, Jean-Marie ;
Burnand, Bernard ;
Rossetti, Andrea O. .
EPILEPSIA, 2011, 52 (07) :1292-1296
[3]   Lacosamide: An investigational drug for adjunctive treatment of partial-onset seizures [J].
Ben-Menachem, Elinor .
DRUGS OF TODAY, 2008, 44 (01) :35-40
[4]   Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures [J].
Ben-Menachem, Elinor ;
Biton, Victor ;
Jatuzis, Dalius ;
Abou-Khalil, Bassel ;
Doty, Pamela ;
Rudd, G. David .
EPILEPSIA, 2007, 48 (07) :1308-1317
[5]  
Benhaddi H., MEDICOECONOMIC EVALU
[6]   Intravenous levetiracetam as treatment for status epilepticus [J].
Berning, Sascha ;
Boesebeck, Frank ;
van Baalen, Andreas ;
Kellinghaus, Christoph .
JOURNAL OF NEUROLOGY, 2009, 256 (10) :1634-1642
[7]   Progress report on new antiepileptic drugs: A summary of the Eigth Eflat Conference (EILAT VIII) [J].
Bialer, Meir ;
Johannessen, Svein I. ;
Kupferberg, Harvey J. ;
Levy, Rene H. ;
Perucca, Emilio ;
Tomson, Torbjorn .
EPILEPSY RESEARCH, 2007, 73 (01) :1-52
[8]   Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures [J].
Biton, Victor ;
Rosenfeld, William E. ;
Whitesides, John ;
Fountain, Nathan B. ;
Vaiciene, Nerija ;
Rudd, G. David .
EPILEPSIA, 2008, 49 (03) :418-424
[9]   Lacosamide as treatment of epileptic seizures - cost utility results for Sweden [J].
Bolin, K. ;
Berggren, F. ;
Forsgren, L. .
ACTA NEUROLOGICA SCANDINAVICA, 2010, 121 (06) :406-412
[10]   Examining the Clinical Utility of Lacosamide Pooled Analyses of Three Phase II/III Clinical Trials [J].
Chung, Steve ;
Ben-Menachem, Elinor ;
Sperling, Michael R. ;
Rosenfeld, William ;
Fountain, Nathan B. ;
Benbadis, Selim ;
Hebert, David ;
Isojaervi, Jouko ;
Doty, Pamela .
CNS DRUGS, 2010, 24 (12) :1041-1054
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