Development of an amperometric sensor for simultaneous determination of uric acid and ascorbic acid using 2-[bis(2-aminoethyl)amino]ethanol, 4,4′- bipyridine bridged dicopper(II) complex

被引：9

作者：

Wang, Ming Yan ^{[1
,2
]}

Xu, Xing You ^{[1
,2
]}

Yang, Fan ^{[1
]}

Zhang, Sheng Yu ^{[1
]}

Yang, Xu Jie ^{[2
]}

机构：

[1] Huaihai Inst Technol, Dept Chem Engn, Lianyungang 222005, Jiangsu Prov, Peoples R China

[2] Nanjing Univ Sci & Technol, Lab Mat Chem, Nanjing 210094, Peoples R China

来源：

JOURNAL OF APPLIED ELECTROCHEMISTRY | 2008年 / 38卷 / 09期

关键词：

binuclear copper complex; uric acid; ascorbic acid; modified electrode; cyclic voltammetry; differential pulse voltammetry;

D O I：

10.1007/s10800-008-9552-0

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

Binuclear copper complex (2-[bis(2-aminoethyl)amino]ethanol, 4,4'-bipyridine bridged dicopper(II) complex) was grafted onto the surface of a glassy carbon electrode (GCE) using the cyclic voltammetric method in a phosphate buffer solution (PBS). The modified electrode resulted in efficient electrocatalytic activity for anodic oxidation of uric acid (UA) and ascorbic acid (AA) via a substantial decrease in anodic over-potentials for both compounds. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) using this modified electrode result in two well-resolved anodic waves for the oxidation of UA and AA in mixed solution, making possible the simultaneous determination of both compounds. Linear analytical curves were obtained in the ranges 5.0-300.0 mu M and 5.0-160.0 mu M for UA and AA concentrations through DPV methods, respectively. The detection limits were 2.0 mu M of UA and AA. This electrode was used for UA and AA determinations in urine samples with satisfactory results.

引用

页码：1269 / 1274

页数：6

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