Rewriting the past: de novo activity of PRC2 restores global H3K27 methylation patterns

被引：2

作者：

Sharif, Jafar ^{[1
]}

Koseki, Haruhiko ^{[1
]}

机构：

[1] RIKEN, Dev Genet Grp, Ctr Integrat Med Sci IMS, Yokohama, Kanagawa, Japan

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2018年 / 25卷 / 03期

关键词：

H2A UBIQUITYLATION; CPG ISLANDS; COMPLEX; RECRUITMENT; GENES; EZH2; DNA;

D O I：

10.1038/s41594-018-0039-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inheritance of Polycomb repressive complex 2 (PRC2)-mediated gene silencing involves self-propagation of histone H3 lysine 27 (H3K27) methylation from an initial nucleation site, but how the first H3K27 methylation marks are established is not fully understood. A recent study reveals that PRC2 can reconstitute H3K27 methylation de novo in cells that have lost the mark. This reconstitution is dependent on the PRC2 core component SUZ12, which provides a novel link between initiation and self-propagation of this critical epigenetic mark.

引用

页码：197 / 199

页数：4

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