Frajunolides E-K, briarane diterpenes from Junceella fragilis

被引：39

作者：

Liaw, Chia-Ching ^{[2
]}

Shen, Ya-Ching ^{[1
]}

Lin, Yun-Sheng ^{[2
]}

Hwang, Tsong-Long ^{[3
]}

Kuo, Yao-Haur ^{[4
]}

Khalil, Ashraf Taha ^{[1
]}

机构：

[1] Natl Taiwan Univ, Sch Pharm, Coll Med, Taipei 100, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[3] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[4] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期

关键词：

D O I：

10.1021/np800126f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.

引用

页码：1551 / 1556

页数：6

共 29 条

[1] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].