The role of the NLRP3 inflammasome in pulmonary diseases

被引：134

作者：

Hosseinian, Nima ^{[1
]}

Cho, Young ^{[1
]}

Lockey, Richard F. ^{[1
]}

Kolliputi, Narasaiah ^{[1
]}

机构：

[1] Univ S Florida, Div Allergy & Immunol, Dept Internal Med, Morsani Coll Med, Tampa, FL 33612 USA

来源：

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE | 2015年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

acute lung injury; chronic respiratory disease; inflammasome; inflammation; interleukin; 1; lung; NLRP3; EPITHELIAL-MESENCHYMAL TRANSITION; ALLERGIC AIRWAY INFLAMMATION; INDUCED LUNG INJURY; NALP3; INFLAMMASOME; OXIDATIVE STRESS; HOST-DEFENSE; ACTIVATION; FIBROSIS; CELLS; RELEASE;

D O I：

10.1177/1753465815586335

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Respiratory diseases and lung injuries are one of the leading causes of death in the world. One critical component of these diseases is exaggerated inflammatory response. The recently discovered inflammasome is believed to play a key role in inflammation. The inflammasome is an oligomer of intracellular proteins that, once activated by an insult or damage signal, produces mature cytokines from the interleukin-1 family that mediate an inflammatory response. Previous research has provided evidence that suggests the role of the inflammasome in the pathogenesis of many chronic respiratory diseases and acute lung injuries, such as transfusion-related acute lung injury, ventilator-induced lung injury, asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. This article summarizes recent research on the inflammasome and reviews proposed molecular models of the role of the inflammasome in several prominent lung diseases and injuries.

引用

页码：188 / 197

页数：10

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