Viral clearance without destruction of infected cells during acute HBV infection

被引：979

作者：

Guidotti, LG

Rochford, R

Chung, J

Shapiro, M

Purcell, R

Chisari, FV ^{[1
]}

机构：

[1] Scripps Res Inst, Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

[2] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

[3] Bioqual Inc, Rockville, MD 20850 USA

[4] NIH, Bethesda, MD 20892 USA

来源：

SCIENCE | 1999年 / 284卷 / 5415期

关键词：

D O I：

10.1126/science.284.5415.825

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected hepatocytes by CD8(+) T lymphocytes. However, in this study, HBV DNA was shown to Largely disappear from the Liver and the blood of acutely infected chimpanzees Long before the peak of T cell infiltration and most of the Liver disease. These results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.

引用

页码：825 / 829

页数：5

共 25 条

[1] HEPATITIS-B VIRUS-INFECTION IN CHIMPANZEES - TITRATION OF SUBTYPES [J].