Method in the Madness - Methodology from Total Synthesis

被引：1

作者：

Pouwer, Rebecca H. ^{[2
]}

Williams, Craig M. ^{[1
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4111, Australia

[2] Griffith Univ, Eskitis Inst Cell & Mol Therapies, Nathan, Qld 4111, Australia

来源：

SYNLETT | 2012年 / 10期

关键词：

natural products; total synthesis; synthetic methodology; chemical reactivity; organometallics; cyclohexanes; C-20 DITERPENE ALKALOIDS; BAYLIS-HILLMAN REACTION; CYCLIC ENONES; SILVER(I) ACETYLIDES; DIRECT ACCESS; RAIN-FOREST; ACID IBX; REARRANGEMENT; ALKYNYLATION; DERIVATIVES;

D O I：

10.1055/s-0031-1290967

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A review surveying the synthetic methodology developed by the Williams group over the last ten years, driven by natural product total synthesis, is presented. An underlying theme over this time has been the reliance on physical organic chemistry, organometallics and the cyclohexane ring system.

引用

页码：1446 / 1458

页数：13

共 34 条

[31] Nitrogen is a requirement for the photochemical induced 3-azabicyclo[3.3.1]nonane skeletal rearrangement! [J].

Williams, CM ;

Heim, R ;

Bernhardt, PV .

TETRAHEDRON, 2005, 61 (15) :3771-3779

[32] Investigating direct routes to an advanced intermediate for the synthesis of C-20 diterpene alkaloids [J].

Williams, CM ;

Mander, LN ;

Bernhardt, PV ;

Willis, AC .

TETRAHEDRON, 2005, 61 (15) :3759-3769

[33] Unprecedented photochemical induced cascading rearrangement of the 3-azabicyclo[3.3.1] nonane skeleton [J].

Williams, CM ;

Heim, R ;

Brecknell, DJ ;

Bernhardt, PV .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (06) :806-807

[34] Bridgehead arylation: A direct route to advanced intermediates for the synthesis of C-20 diterpene alkaloids [J].

Williams, CM ;

Mander, LN .

ORGANIC LETTERS, 2003, 5 (19) :3499-3502

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