Does shear wave ultrasound independently predict axillary lymph node metastasis in women with invasive breast cancer?

被引:116
作者
Evans, Andrew [1 ]
Rauchhaus, Petra [2 ]
Whelehan, Patsy [1 ]
Thomson, Kim [1 ]
Purdie, Colin A. [1 ]
Jordan, Lee B. [1 ]
Michie, Caroline O. [1 ]
Thompson, Alastair [1 ]
Vinnicombe, Sarah [1 ]
机构
[1] Univ Dundee, Ninewells Hosp & Med Sch, Dundee Canc Ctr, Dundee DD1 9SY, Scotland
[2] Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth Sci, Dundee DD1 9SY, Scotland
基金
英国工程与自然科学研究理事会;
关键词
Breast cancer; Prognosis; Elastography; Metastasis; NEEDLE CORE BIOPSY; DIFFERENTIATING BENIGN; ELASTOGRAPHY; CHEMOTHERAPY; MASSES; US; SIGNATURE; NOMOGRAM; SURVIVAL; TUMOR;
D O I
10.1007/s10549-013-2747-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Shear wave elastography (SWE) shows promise as an adjunct to greyscale ultrasound examination in assessing breast masses. In breast cancer, higher lesion stiffness on SWE has been shown to be associated with features of poor prognosis. The purpose of this study was to assess whether lesion stiffness at SWE is an independent predictor of lymph node involvement. Patients with invasive breast cancer treated by primary surgery, who had undergone SWE examination were eligible. Data were retrospectively analysed from 396 consecutive patients. The mean stiffness values were obtained using the Aixplorer(A (R)) ultrasound machine from SuperSonic Imagine Ltd. Measurements were taken from a region of interest positioned over the stiffest part of the abnormality. The average of the mean stiffness value obtained from each of two orthogonal image planes was used for analysis. Associations between lymph node involvement and mean lesion stiffness, invasive cancer size, histologic grade, tumour type, ER expression, HER-2 status and vascular invasion were assessed using univariate and multivariate logistic regression. At univariate analysis, invasive size, histologic grade, HER-2 status, vascular invasion, tumour type and mean stiffness were significantly associated with nodal involvement. Nodal involvement rates ranged from 7 % for tumours with mean stiffness < 50 kPa to 41 % for tumours with a mean stiffness of > 150 kPa. At multivariate analysis, invasive size, tumour type, vascular invasion, and mean stiffness maintained independent significance. Mean stiffness at SWE is an independent predictor of lymph node metastasis and thus can confer prognostic information additional to that provided by conventional preoperative tumour assessment and staging.
引用
收藏
页码:153 / 157
页数:5
相关论文
共 27 条
[1]   Shear-wave Elastography Improves the Specificity of Breast US: The BE1 Multinational Study of 939 Masses [J].
Berg, Wendie A. ;
Cosgrove, David O. ;
Dore, Caroline J. ;
Schaefer, Fritz K. W. ;
Svensson, William E. ;
Hooley, Regina J. ;
Ohlinger, Ralf ;
Mendelson, Ellen B. ;
Balu-Maestro, Catherine ;
Locatelli, Martina ;
Tourasse, Christophe ;
Cavanaugh, Barbara C. ;
Juhan, Valerie ;
Stavros, A. Thomas ;
Tardivon, Anne ;
Gay, Joel ;
Henry, Jean-Pierre ;
Cohen-Bacrie, Claude .
RADIOLOGY, 2012, 262 (02) :435-449
[2]   Doctor, what are my chances of having a positive sentinel node? A validated nomogram for risk estimation [J].
Bevilacqua, Jose Luiz B. ;
Kattan, Michael W. ;
Fey, Jane V. ;
Cody, Hiram S., III ;
Borgen, Patrick I. ;
Van Zee, Kimberly J. .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (24) :3670-3679
[3]   The role of sentinel lymph node surgery in patients presenting with node positive breast cancer (T0-T4, N1-2) who receive neoadjuvant chemotherapy - results from the ACOSOG Z1071 trial [J].
Boughey, J. C. ;
Suman, V. J. ;
Mittendorf, E. A. ;
Ahrendt, G. M. ;
Wilke, L. G. ;
Taback, B. ;
Leitch, A. M. ;
Flippo-Morton, T. S. ;
Byrd, D. R. ;
Ollila, D. W. ;
Julian, T. B. ;
McLaughlin, S. A. ;
McCall, L. ;
Symmans, W. F. ;
Le-Petross, H. T. ;
Haffty, B. G. ;
Buchholz, T. A. ;
Hunt, K. K. .
CANCER RESEARCH, 2012, 72
[4]   Differentiating benign from malignant solid breast masses with US strain imaging [J].
Burnside, Elizabeth S. ;
Hall, Timothy J. ;
Sommer, Amy M. ;
Hesley, Gina K. ;
Sisney, Gale A. ;
Svensson, William E. ;
Fine, Jason P. ;
Jiang, Jinfeng ;
Hangiandreou, Nicholas J. .
RADIOLOGY, 2007, 245 (02) :401-410
[5]   Clinical application of shear wave elastography (SWE) in the diagnosis of benign and malignant breast diseases [J].
Chang, Jung Min ;
Moon, Woo Kyung ;
Cho, Nariya ;
Yi, Ann ;
Koo, Hye Ryoung ;
Han, Wonsik ;
Noh, Dong-Young ;
Moon, Hyeong-Gon ;
Kim, Seung Ja .
BREAST CANCER RESEARCH AND TREATMENT, 2011, 129 (01) :89-97
[6]   Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway [J].
Chen, Li-Ching ;
Tu, Shih-Hsin ;
Huang, Ching-Shui ;
Chen, Ching-Shyang ;
Ho, Chi-Tang ;
Lin, Hsiao-Wei ;
Lee, Chia-Hwa ;
Chang, Hui-Wen ;
Chang, Chien-Hsi ;
Wu, Chih-Hsiung ;
Lee, Wen-Sen ;
Ho, Yuan-Soon .
BREAST CANCER RESEARCH AND TREATMENT, 2012, 134 (03) :989-1004
[7]   Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma [J].
Conklin, Matthew W. ;
Eickhoff, Jens C. ;
Riching, Kristin M. ;
Pehlke, Carolyn A. ;
Eliceiri, Kevin W. ;
Provenzano, Paolo P. ;
Friedl, Andreas ;
Keely, Patricia J. .
AMERICAN JOURNAL OF PATHOLOGY, 2011, 178 (03) :1221-1232
[8]   Shear wave elastography for breast masses is highly reproducible [J].
Cosgrove, David O. ;
Berg, Wendie A. ;
Dore, Caroline J. ;
Skyba, Danny M. ;
Henry, Jean-Pierre ;
Gay, Joel ;
Cohen-Bacrie, Claude .
EUROPEAN RADIOLOGY, 2012, 22 (05) :1023-1032
[9]   Differentiating benign from malignant solid breast masses: value of shear wave elastography according to lesion stiffness combined with greyscale ultrasound according to BI-RADS classification [J].
Evans, A. ;
Whelehan, P. ;
Thomson, K. ;
Brauer, K. ;
Jordan, L. ;
Purdie, C. ;
McLean, D. ;
Baker, L. ;
Vinnicombe, S. ;
Thompson, A. .
BRITISH JOURNAL OF CANCER, 2012, 107 (02) :224-229
[10]   Invasive Breast Cancer: Relationship between Shear-wave Elastographic Findings and Histologic Prognostic Factors [J].
Evans, Andrew ;
Whelehan, Patsy ;
Thomson, Kim ;
McLean, Denis ;
Brauer, Katrin ;
Purdie, Colin ;
Baker, Lee ;
Jordan, Lee ;
Rauchhaus, Petra ;
Thompson, Alastair .
RADIOLOGY, 2012, 263 (03) :673-677