Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms

被引：0
作者：
Bottini, N
Bottini, E
Gloria-Bottini, F
Mustelin, T
机构：
[1] Burnham Inst, La Jolla Canc Res Ctr, Program Signal Transduct, La Jolla, CA 92037 USA
[2] Univ Roma Tor Vergata, Dept Neurosci, Rome, Italy
[3] Univ Roma Tor Vergata, Dept Biopathol, Rome, Italy
来源：
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2002年 / 50卷 / 02期
关键词：
tyrosine phosphatase; genetic polymorphisms; allergy; asthma; obesity;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A major challenge in the post-genomic era is to identify the physiological functions of genes and elucidate the molecular basis for human disease. Genetic polymorphisms offer a convenient avenue for these efforts by providing evidence for the involvement of a given gene in human pathophysiology. Here we review the current evidence linking the low-molecular-weight protein tyrosine phosphatase (LMPTP) to several common diseases, including allergy, asthma, obesity, myocardial hypertrophy, and Alzheimer's disease. Based on the known effects of the genetic polymorphisms on the alternative mRNA splicing and enzyme levels of LMPTP, we discuss the possible molecular mechanisms of LMPTP involvement in these diseases.
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收藏
页码：95 / 104
页数：10
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