Characteristics of female lung cancer in Korea: analysis of Korean National Lung Cancer Registry

被引：7

作者：

Lim, Jeong Uk ^{[1
]}

Han, Solji ^{[2
]}

Kim, Ho Cheol ^{[3
]}

Choi, Chang Min ^{[3
]}

Jung, Chi Young ^{[4
]}

Cho, Deog Gon ^{[5
]}

Jeon, Jae Hyun ^{[6
]}

Lee, Jeong Eun ^{[7
]}

Ahn, Jin Seok ^{[8
]}

Kim, Yeongdae ^{[9
]}

Choi, Yoo-Duk ^{[10
]}

Suh, Yang-Gun ^{[11
]}

Kim, Jung-Eun ^{[12
]}

Won, Young-Joo ^{[12
]}

Kim, Young-Chul ^{[13
]}

Park, Chan Kwon ^{[1
]}

Kim, Seung Joon ^{[14
,15
]}

机构：

[1] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med,Coll Med, 62 Yeouido Dong, Seoul 150713, South Korea

[2] Yonsei Univ, Dept Appl Stat, Seoul, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pulm & Crit Care Med, Seoul, South Korea

[4] Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu, South Korea

[5] Catholic Univ Korea, Coll Med, Dept Thorac & Cardiovasc Surg, St Vincents Hosp, Suwon, South Korea

[6] Seoul Natl Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Bundang Hosp, Seoul, South Korea

[7] Chungnam Natl Univ, Div Pulmonol, Dept Internal Med, Daejeon, South Korea

[8] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Seoul, South Korea

[9] Pusan Natl Univ Hosp, Dept Cardiothorac Surg, Pusan, South Korea

[10] Chonnam Natl Univ, Hwasun Hosp, Dept Pathol, Hwasun, South Korea

[11] Natl Canc Ctr, Proton Therapy Ctr, Res Inst & Hosp, Goyang, South Korea

[12] Natl Canc Ctr, Canc Registrat & Stat Branch, Goyang, South Korea

[13] Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Hwasun, South Korea

[14] Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med,Coll Med, Seoul, South Korea

[15] Catholic Univ Korea, Coll Med, Postech Catholic Biomed Engn Inst, Seoul, South Korea

来源：

JOURNAL OF THORACIC DISEASE | 2020年 / 12卷 / 09期

关键词：

Women; lung cancer; smoking; pulmonary function; mortality; OBSTRUCTIVE PULMONARY-DISEASE; FORCED EXPIRATORY VOLUME; VITAL CAPACITY; RISK-FACTORS; WOMEN; MUTATIONS; SURVIVAL; STATISTICS; HISTOLOGY; SMOKING;

D O I：

10.21037/jtd-20-1671

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Backgrounds: The present study evaluated Korean women with lung cancer and compared the clinical characteristics of ever-smoker and never-smoker groups using the National Lung Cancer Registry. Methods: In affiliation with the Korean Central Cancer Registry, the Korean Association for Lung Cancer constructed a registry into which 10% of the lung cancer cases in Korea were registered. Female lung cancer patients with valid smoking history were evaluated. Results: Among 735 female lung cancer patients, 643 (87.5%) were never-smokers and 92 (12.5%) were smokers. The median survival was significantly longer in the never-smoker group (28 vs. 14 months; P<0.(X)1). Among 683 patients with non-small cell lung cancer (NSCLC), the never-smoker group showed significantly longer median survival (29 vs. 14 months; P=0.002) and a higher proportion of stage I cancer (40.3% vs. 25.7%; P<0.(X)1). Survival analysis of the NSCLC patients showed that smoking status, receiving only supportive care, EGFR mutation status, lung cancer stage, and forced vital capacity (FVC) (%) were significantly associated with mortality in the multivariate analysis (P=0.025, HR 2.39, 95% CI: 1.12-5.11; P=0.017, HR 3.14, 95% CI: 1.22-8.06; P=0.033, HR 0.63, 95% CI: 0.41-0.96; P<0.001, HR 11.88, 95% CI: 5.79-24.38; P=0.002, HR 0.98, 95% CI: 0.96-0.99, respectively). Conclusions: In Korean women with NSCLC, smoking status, not receiving active anticancer treatment, EGFR mutation status, lung cancer stage, and pulmonary function were significantly associated with mortality.

引用

页码：4612 / +

页数：12

共 32 条

[1] Invited Commentary: The Etiology of Lung Cancer in Men Compared With Women [J].