Xanthohumol metabolites in faeces of rats

被引：105

作者：

Nookandeh, A

Frank, N

Steiner, F

Ellinger, R

Schneider, B

Gerhäuser, C

Becker, H ^{[1
]}

机构：

[1] Univ Saarland, Inst Pharmacognosy & Analyt Phytochem, D-66041 Saarbrucken, Germany

[2] German Canc Res Ctr, DKFZ, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, Germany

[3] Univ Saarland, D-66041 Saarbrucken, Germany

[4] Max Planck Inst Chem Ecol, D-07745 Jena, Germany

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 05期

关键词：

Humulus lupulus; Cannabaceae; chalcones; faeces; flavanones; HPLC-NMR; metabolites; rat; xanthohumol;

D O I：

10.1016/j.phytochem.2003.11.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Xanthohumol (1), isolated from hop, was fed to rats in a dose of 1000 mg kg(-1) body weight. The faeces of the animals were collected after 24 and 48 h and analysed for metabolites of 1. Approximately 89% of the recovered flavonoid-compounds consisted of unchanged 1. Sixteen metabolites and six previously known metabolites were isolated and characterized by coupling techniques (HPLC-NMR, HPLC-MS and HPLC-DAD). Their structures were elucidated by spectroscopic methods, especially using NMR spectroscopy. Twenty metabolites had a modified chalcone structure and two metabolites were flavanone derivatives. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：561 / 570

页数：10

共 15 条

[1] Prenylated chalcones and flavones from the leaves of Dorstenia kameruniana [J].