Virus-like particles in picornavirus vaccine development

被引：21
作者：
Dong, Hu [1 ]
Guo, Hui-Chen [1 ]
Sun, Shi-Qi [1 ]
机构：
[1] Chinese Acad Agr Sci, State Key Lab Vet Etiol Biol, OIE Natl Foot & Mouth Dis Reference Lab, Lanzhou Vet Res Inst, Lanzhou 730046, Peoples R China
来源：
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2014年 / 98卷 / 10期
关键词：
Picornavirus; Virus-like particles; Vaccine; MOUTH-DISEASE VIRUS; LETHAL ENTEROVIRUS-71 INFECTION; INSECT CELLS; NEUTRALIZING ANTIBODIES; IMMUNE-RESPONSES; CAPSID PROTEINS; EXPRESSING VP1; EMPTY CAPSIDS; PROTECTS MICE; NEWBORN MICE;
D O I：
10.1007/s00253-014-5639-1
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Virus-like particles (VLP), which are similar to natural virus particles but do not contain viral genes, have brought about significant breakthroughs in many research fields because of their unique advantages. The ordered repeating epitopes of VLP can induce immunity responses similar to those prompted by natural viral infection; thus, VLP vaccines are regarded as candidate alternatives to whole-virus vaccines. As picornavirus has serious impacts on human and animal health, the development of efficient and safe vaccines is a key endeavor in preventing virus infections. The characteristics of picornavirus capsid proteins allow the development of VLP vaccines. This paper investigates research scenarios and progress on picornavirus VLP vaccines with the aim of providing a reference for researchers focusing on virology and vaccinology.
引用
收藏
页码：4321 / 4329
页数：9
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