Prognostic value of vascular endothelial growth factor in patients with head and neck cancer: A meta-analysis

被引：30

作者：

Zang, Jian ^{[1
]}

Li, Chen ^{[2
]}

Zhao, Li-Na ^{[1
]}

Shi, Mei ^{[1
]}

Zhou, Yong-Chun ^{[1
]}

Wang, Jian-Hua ^{[1
]}

Li, Xin ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Radiat Oncol, Xian 710032, Peoples R China

[2] Sichuan Univ, Sch Publ Hlth, Dept Hlth Stat, Chengdu 610064, Peoples R China

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2013年 / 35卷 / 10期

关键词：

vascular endothelial growth factor; prognosis; head and neck cancer; meta-analysis; survival; SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASIS; SALIVARY-GLAND CARCINOMAS; FACTOR-C EXPRESSION; ORAL TONGUE CANCER; FACTOR-KAPPA-B; NASOPHARYNGEAL CARCINOMA; MICROVESSEL DENSITY; VEGF-C; VESSEL DENSITY;

D O I：

10.1002/hed.23156

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundThe correlation between vascular endothelial growth factor (VEGF) overexpression and the clinical outcome of head and neck cancer remains inconclusive. This meta-analysis aimed to evaluate the prognostic value of VEGF in patients with head and neck cancer. MethodsWe searched Ovid MEDLINE, EMBASE and 2 Chinese science databases in order to enroll all eligible articles. Forty-seven studies were included in this meta-analysis. All results were evaluated by the random-effects model. ResultsVEGF overexpression is significantly associated with worse overall survival (OS; hazard ratio [HR], 1.89; 95% confidence interval [CI], 1.61-2.22) and progression-free survival (PFS; HR, 1.68; 95% CI, 1.33-2.12). Subgroup analysis reveals that VEGF overexpression is a significant poor predictor for nasopharyngeal cancer (HR, 1.66; 95% CI, 1.30-2.12) and salivary gland cancer (HR, 3.32; 95% CI, 1.61-6.84). ConclusionOur meta-analysis supports that VEGF overexpression is an available poor predictor for patients with head and neck cancer. (c) 2012 Wiley Periodicals, Inc. Head Neck 35: 1507-1514, 2013

引用

页码：1507 / 1514

页数：8

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