Dose-depending effect of intracerebroventricularly administered bradykinin on nociception in rats

被引：7

作者：

Bujalska-Zadrozny, Magdalena ^{[1
]}

de Corde, Anna ^{[1
]}

Cegielska-Perun, Krystyna ^{[1
]}

Gasinska, Emilia ^{[1
]}

Makulska-Nowak, Helena ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Pharmacodynam, PL-00927 Warsaw 64, Poland

来源：

PHARMACOLOGICAL REPORTS | 2013年 / 65卷 / 04期

关键词：

bradykinin; intracerebroventricular; B-1/B-2 receptor antagonists; antinociception; nociception; dose-response relationship; rats; SPINAL-CORD; KININ B-1; RECEPTOR; RESPONSES; LOCALIZATION; INVOLVEMENT; ANTAGONISTS; BRAIN; PAIN; MICE;

D O I：

10.1016/S1734-1140(13)71082-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: The effect of small and high doses of intracerebroventricularly (icy) applied bradykinin (BK) on nociception produced by mechanical stimuli and the participation of B-1 and B-2 receptors in this nociception were investigated in rats. Results: BK at the lowest dose (0.06 mu g) produced hyperalgesia whereas at the higher doses (6 and 12 mu g) antinociception. This effect was abolished by B-1 or B-2 receptor antagonists, des-Arg(10)-HOE140 and HOE140 (1 pmol icv), respectively. Conclusion: Depending on the dose used, BK produces pro- or anti-nociceptive action. Both B-1 and B-2 receptors are involved in the action of icy applied BK.

引用

页码：1006 / 1011

页数：6

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